ArticlePloS one2013
Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Associations Between Pre-Transplantation T Cell Populations and Acute Cellular Rejection Post-Liver Transplantation-Results From a Prospective Cohort Study.Scandinavian journal of immunology · 2025Article
- Strategies for Liver Transplantation Tolerance.International journal of molecular sciences · 2021Review
- Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Simultaneous Recognition of Allogeneic MHC and Cognate Autoantigen by Autoreactive T Cells in Transplant Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8Frontiers in immunology · 2018Article
- Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.Transplantation · 2016Article
- Article
- Memory T cells in organ transplantation: progress and challenges.Nature reviews. Nephrology · 2016Review
- Targeting CD8 T-Cell Metabolism in Transplantation.Frontiers in immunology · 2015Review
- What's new in clinical solid organ transplantation by 2013.World journal of transplantation · 2014Review
- Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation.Clinical epigeneticsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effector and regulatory T cell subpopulations involved in the development of acute rejection episodes in lung transplantation remain to be elucidated. Twenty-seven lung transplant candidates were prospectively monitored before transplantation and within the first year post-transplantation. Regulatory, Th17, memory and naïve T cells were measured in peripheral blood of lung transplant recipients by flow cytometry. No association of acute rejection with number of peripheral regulatory T cells and Th17 cells was found. However, effector memory subsets in acute rejection patients were increased during the first two months post-transplant. Interestingly, patients waiting for lung transplant with levels of CD8(+) effector memory T cells over 185 cells/mm(3) had a significant increased risk of rejection [OR: 5.62 (95% CI: 1.08-29.37), p=0.04]. In multivariate analysis adjusted for age and gender the odds ratio for rejection was: OR: 5.89 (95% CI: 1.08-32.24), p=0.04. These data suggest a correlation between acute rejection and effector memory T cells in lung transplant recipients. The measurement of peripheral blood CD8(+) effector memory T cells prior to lung transplant may define patients at high risk of acute lung rejection.
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