ArticlePloS one2013
Runx3-mediated transcriptional program in cytotoxic lymphocytes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 65 citations in OpenAlex.
- Arid3b suppresses CD8 + T cell infiltration and function in microsatellite-stable colorectal cancer via Runx3.Nature communications · 2026Article
- Integrated profiling of RUNX3 in intratumoral NK cells activity through bulk and single-cell transcriptomic analysis.Frontiers in immunology · 2026Article
- An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation.Scientific reports · 2024Article
- Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species.Cell communication and signaling : CCS · 2024Article
- Cis-regulatory evolution of the recently expanded Ly49 gene family.Nature communications · 2024Article
- Runx3 Regulates CD8International journal of molecular sciences · 2024Article
- Vorinostat-induced acetylation of RUNX3 reshapes transcriptional profile through long-range enhancer-promoter interactions in natural killer cells.BMB reports · 2023Article
- TRIB2 safeguards naive T cell homeostasis during aging.Cell reports · 2023Article
- RUNX3 improves CAR-T cell phenotype and reduces cytokine release while maintaining CAR-T function.Medical oncology (Northwood, London, England) · 2023Article
- Review
- Newly recruited intraepithelial Ly6AImmunity · 2022Article
- Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells.Cold Spring Harbor perspectives in biology · 2022Review
- Biology and clinical relevance of follicular cytotoxic T cells.Frontiers in immunology · 2022Review
- Runx3 regulates iron metabolism via modulation of BMP signalling.Cell proliferation · 2021Article
- Distinct Repopulation Activity in Hu-Mice Between CB- and LPB-CD34International journal of stem cells · 2021Article
- Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development.Immunological reviews · 2021Review
- Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.Frontiers in immunology · 2021Article
- Ascorbic Acid PromotesJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Review
- Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.The Journal of experimental medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3(-/-) primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and IL-2-activated states. Runx3-bound genomic regions in both cell types were distantly located relative to gene transcription start sites and were enriched for RUNX and ETS motifs. Bound genomic regions significantly overlapped T-bet and p300-bound enhancer regions in Runx3-expressing Th1 helper cells. Compared to resting cells, IL-2-activated CD8(+) T and NK cells contain three times more Runx3-regulated genes that are common to both cell types. Functional annotation of shared CD8(+) T and NK Runx3-regulated genes revealed enrichment for immune-associated terms including lymphocyte activation, proliferation, cytotoxicity, migration and cytokine production, highlighting the role of Runx3 in CD8(+) T and NK activated cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.