ArticlePloS one2013
Diet-induced obesity reduces the responsiveness of the peripheral taste receptor cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Taste Changes after Bariatric Surgery: a Systematic Review.Obesity surgery · 2018Pooled it
- Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.Nature communications · 2026Article
- Taste Plasticity in Nutrition and Health: A Scoping Review.Nutrients · 2025Article
- Fat taste responsiveness, but not dietary fat intake, is affected inbioRxiv : the preprint server for biology · 2025Article
- Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025Review
- Nutrient Sensing by Lingual G-Protein-Coupled Taste Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Daily GDF15 treatment has sex-specific effects on body weight and food intake and does not enhance the effects of voluntary physical activity in mice.The Journal of physiology · 2024Article
- Article
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- Altered peripheral taste function in a mouse model of inflammatory bowel disease.Scientific reports · 2023Article
- High-sucrose diet exposure is associated with selective and reversible alterations in the rat peripheral taste system.Current biology : CB · 2022Article
- Article
- Article
- Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats.Nutrients · 2021Article
- Glucagon-like peptide-1, a matter of taste?Reviews in endocrine & metabolic disorders · 2021Review
- Impact of Nutritional Intervention on Taste Perception-A Scoping Review.Foods (Basel, Switzerland) · 2021Article
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet.Nutrients · 2021Article
- Obesity-induced taste dysfunction, and its implications for dietary intake.International journal of obesity (2005) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObesity is a growing epidemic that causes many serious health related complications. While the causes of obesity are complex, there is conclusive evidence that overconsumption coupled with a sedentary lifestyle is the primary cause of this medical condition. Dietary consumption is controlled by appetite which is in turn regulated by multiple neuronal systems, including the taste system. However, the relationship between taste and obesity has not been well defined. Growing evidence suggests that taste perception in the brain is altered in obese animals and humans, however no studies have determined if there are altered taste responses in the peripheral taste receptor cells, which is the initiation site for the detection and perception of taste stimuli. METHODOLOGY/PRINCIPAL
findingsIn this study, we used C57Bl/6 mice which readily become obese when placed on a high fat diet. After ten weeks on the high fat diet, we used calcium imaging to measure how taste-evoked calcium signals were affected in the obese mice. We found that significantly fewer taste receptor cells were responsive to some appetitive taste stimuli while the numbers of taste cells that were sensitive to aversive taste stimuli did not change. Properties of the taste-evoked calcium signals were also significantly altered in the obese mice. Behavioral analyses found that mice on the high fat diet had reduced ability to detect some taste stimuli compared to their littermate controls. CONCLUSIONS/SIGNIFICANCE: Our findings demonstrate that diet-induced obesity significantly influences peripheral taste receptor cell signals which likely leads to changes in the central taste system and may cause altered taste perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.