ArticlePloS one2013
MDR-ER: balancing functions for adjusting the ratio in risk classes and classification errors for imbalanced cases and controls using multifactor-dimensionality reduction.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genome-wide association and MaODR-based multi-locus interaction analyses reveal a susceptibility gene network for newly identified metabolic syndrome.Genome biology · 2026Article
- SEEI: spherical evolution with feedback mechanism for identifying epistatic interactions.BMC genomics · 2024Article
- Identification of mortality-risk-related missense variant for renal clear cell carcinoma using deep learning.Therapeutic advances in chronic disease · 2021Article
- Higher-order clinical risk factor interaction analysis for overall mortality in maintenance hemodialysis patients.Therapeutic advances in chronic disease · 2020Article
- Article
- Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses.BioMed research international · 2017Article
- An efficiency analysis of high-order combinations of gene-gene interactions using multifactor-dimensionality reduction.BMC genomics · 2015Article
- The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese.BioMed research international · 2015Article
- High order gene-gene interactions in eight single nucleotide polymorphisms of renin-angiotensin system genes for hypertension association study.BioMed research international · 2015Article
- Weighted risk score-based multifactor dimensionality reduction to detect gene-gene interactions in nasopharyngeal carcinoma.International journal of molecular sciences · 2014Article
- Double-bottom chaotic map particle swarm optimization based on chi-square test to determine gene-gene interactions.BioMed research international · 2014Article
- Identification of SNP barcode biomarkers for genes associated with facial emotion perception using particle swarm optimization algorithm.Annals of general psychiatry · 2014Article
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5 authors.
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Abstract
backgroundDetermining the complex relationship between diseases, polymorphisms in human genes and environmental factors is challenging. Multifactor dimensionality reduction (MDR) has proven capable of effectively detecting statistical patterns of epistasis. However, MDR has its weakness in accurately assigning multi-locus genotypes to either high-risk and low-risk groups, and does generally not provide accurate error rates when the case and control data sets are imbalanced. Consequently, results for classification error rates and odds ratios (OR) may provide surprising values in that the true positive (TP) value is often small. METHODOLOGY/PRINCIPAL
findingsTo address this problem, we introduce a classifier function based on the ratio between the percentage of cases in case data and the percentage of controls in control data to improve MDR (MDR-ER) for multi-locus genotypes to be classified correctly into high-risk and low-risk groups. In this study, a real data set with different ratios of cases to controls (1:4) was obtained from the mitochondrial D-loop of chronic dialysis patients in order to test MDR-ER. The TP and TN values were collected from all tests to analyze to what degree MDR-ER performed better than MDR. CONCLUSIONS/SIGNIFICANCE: Results showed that MDR-ER can be successfully used to detect the complex associations in imbalanced data sets.
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