ArticleAfrican health sciences2013
The outcome of non-carbapenem-based empirical antibacterial therapy and VRE colonisation in patients with hematological malignancies.
Article in African health sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Prevalence of Extended-Spectrum Beta-Lactamase-ProducingInfection and drug resistance · 2020Article
- Antibiotic resistance status and its costs in hematological patients: A two-year analysis.Caspian journal of internal medicine · 2017Article
- Which Multidrug-Resitant Bacteria are Emerging in Patients with Hematological Malignancies?: One-Year Report.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2015Article
- Bloodstream infections in patients with hematological malignancies: which is more fatal - cancer or resistant pathogens?Therapeutics and clinical risk management · 2014Article
- Nodding syndrome, infections and sexuality.African health sciences · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundFebrile neutropenia (FN) is generally a complication of cancer chemotherapy.
objectivesWe retrospectively evaluated the febrile neutropenia episodes and their outcomes with respect to modification rates of non-carbapenem-based empirical antibacterial therapy and vancomycin-resistant enterococcus (VRE) colonisation that caused to VRE bacteremia in patients with hematological malignancies.
methodsAll consecutive patients, who were older than 14 years of age and developed febrile neutropenia episodes due to hematological malignancies from September 2010 to November 2011 at the hematology department were included into the study.
resultsIn total, 86 consecutive neutropenic patients and their 151 febrile episodes were evaluated. The mean MASCC prognostic index score was 18,72 ± 9,43. Among 86 patients, 28 patients experienced a total of 30 bacteremia episodes of bacterial origin. Modification rates of both, empirical monotherapy and combination therapies, were found similar, statistically (P = 0,840).
conclusionsOur results suggest that initiating of non-carbapenem based therapy does not provide high response rates in the treatment of febrile neutropenia attacks. Furthermore, non-carbapenem-based empirical therapy provides benefit in regard to cost-effectiveness and antimicrobial stewardship when local antibiotic resistance patterns of gram-negative bacteria are considered. Patients who are colonized with VRE are more likely to develop bacteremia with VRE strains as a result of invasive procedures and severe damage of mucosal barriers observed in this group of patients.
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