ReviewTheScientificWorldJournal2013
Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal.
Review in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial.European archives of psychiatry and clinical neuroscience · 2016Trial
- Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity.Drug and alcohol dependence · 2015Trial
- Thiamine Deficiency and Brain Injury: Neuroanatomical Changes in the Wernicke-Korsakoff Syndrome.Cureus · 2025Review
- Wernicke's encephalopathy in a terminally ill patient with primary cervical cancer: A case report and literature review.Oncology letters · 2025Article
- The association of vitamin deficiency with depression risk in late-life depression: a review.Frontiers in nutrition · 2025Review
- Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging.Advances in experimental medicine and biology · 2025Review
- The Effects of Thiamine Supplementation on General Health and Infertility Treatment Outcomes in Women with Polycystic Ovary Syndrome: A Triple-Blinded Randomized Placebo-Controlled Clinical Trial.International journal of fertility & sterility · 2024Article
- Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency.Journal of neuroinflammation · 2022Article
- Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Radiosynthesis of 5-[Molecules (Basel, Switzerland) · 2021Article
- Wernicke's encephalopathy post hyperemesis gravidarum misdiagnosed as Guillain-Barre syndrome: lessons for the frontline.BMJ case reports · 2021Article
- Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice.Brain sciences · 2020Article
- Considerations and Current Trends in the Management of the Geriatric Patient on a Consultation-Liaison Service.Current psychiatry reports · 2020Review
- Thiamine Deficiency Modulates p38Neurochemical research · 2020Article
- B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin.CNS neuroscience & therapeutics · 2020Review
- Vertical nystagmus in Wernicke's encephalopathy: pathogenesis and role of central processing of information from the otoliths.Journal of neurology · 2019Article
- Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature.The American journal of case reports · 2019Article
- Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.Frontiers in psychiatry · 2019Review
- Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction.International review of neurobiology · 2019Review
- Amprolium exposure alters mice behavior and metabolism in vivo.Animal models and experimental medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional deficiency can cause, mainly in chronic alcoholic subjects, the Wernicke encephalopathy and its chronic neurological sequela, the Wernicke-Korsakoff syndrome (WKS). Long-term chronic ethanol abuse results in hippocampal and cortical cell loss. Thiamine deficiency also alters principally hippocampal- and frontal cortical-dependent neurochemistry; moreover in WKS patients, important pathological damage to the diencephalon can occur. In fact, the amnesic syndrome typical for WKS is mainly due to the damage in the diencephalic-hippocampal circuitry, including thalamic nuclei and mammillary bodies. The loss of cholinergic cells in the basal forebrain region results in decreased cholinergic input to the hippocampus and the cortex and reduced choline acetyltransferase and acetylcholinesterase activities and function, as well as in acetylcholine receptor downregulation within these brain regions. In this narrative review, we will focus on the neurochemical, neuroanatomical, and neuropsychological studies shedding light on the effects of thiamine deficiency in experimental models and in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.