ArticleSaudi journal of biological sciences2013
Analgesic and anti-inflammatory studies of cyclopeptide alkaloid fraction of leaves of Ziziyphus nummularia.
Article in Saudi journal of biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A Systematic Review of Traditionally Used Herbs and Animal-Derived Products as Potential Analgesics.Current neuropharmacology · 2021Pooled it
- Review
- Genus Ziziphus for the treatment of chronic inflammatory diseases.Saudi journal of biological sciences · 2021Review
- GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies ofMolecules (Basel, Switzerland) · 2020Article
- Anti-Proliferative, Analgesic and Anti-Inflammatory Properties ofMolecules (Basel, Switzerland) · 2020Article
- The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers.BioMed research international · 2020Article
- Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential ofSaudi journal of biological sciences · 2018Article
- Studies on analgesic, anti-inflammatory activities of stem and roots ofJournal of traditional and complementary medicine · 2017Article
- The application of graphene oxidized combining with decellularized scaffold to repair of sciatic nerve injury in rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Article
- Article
- Anti-inflammatory activity of bartogenic acid containing fraction of fruits ofJournal of traditional and complementary medicine · 2017Article
- Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes.3 Biotech · 2016Article
- Phytochemical and Antinociceptive, Anti-Inflammatory, and Antioxidant Studies ofEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Pharmacological basis of the use of the root bark of Zizyphus nummularia Aubrev. (Rhamnaceae) as anti-inflammatory agent.BMC complementary and alternative medicine · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ziziyphus nummularia (family: Rhamnaceae) is a thorny small bush, grows in abundance in the grazing lands of the arid areas of Rajasthan, India. It is an important ethnomedicinal plant of the Thar Desert; local inhabitants use every part of the plant as medicine. Kernels are prescribed in pregnancy as soporific, antiemetic and for relieving abdominal pain. The insect gall is powered and given orally with water to cure bone fracture. Crushed root is applied on the paining shoulder of the bullock. The decoction of leaves is used for the treatment of cough and cold; leaves are also regarded as diaphoretic and prescribed in typhoid. Paste of leaves is used for healing of cuts, boils and cutaneous disease. It is widely used in pain and inflammatory conditions. Z. nummularia contains a unique group of alkaloids known as cyclopeptide alkaloids, in continuation of our work carried out on the leaves of Z. nummularia , present study was initiated to explore antiinflammatory and analgesic potential of cyclopeptide alkaloids isolated from the leaves of Z. nummularia (IFZN). Anti-inflammatory activity was tested against rat paw oedema, mouse peritonitis and cotton pellet granuloma. For screening of analgesic activity, acetic acid induced writhing, tail flick and hot plate test were performed. IFZN 30 mg/kg shows the anti-oedematogenic effect against paw oedema induced by carrageenan, dextran, serotonin and histamine; IFZN 20 and 30 mg/kg were found to have highly significant anti-nociceptive effects. Result of pharmacological studies indicated that IFZN is a potent and efficacious analgesic agent. The analgesic activity of IFZN is mediated by the peripheral as well as central pathways.
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