ReviewInternational journal of chronic obstructive pulmonary disease2013
Pathophysiology and clinical implications of pulmonary arterial enlargement in COPD.
Review in International journal of chronic obstructive pulmonary disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- CT-base pulmonary artery measurement in the detection of pulmonary hypertension: a meta-analysis and systematic review.Medicine · 2014Pooled it
- Vascular-related proteomic signatures in COPD with suspected pulmonary hypertension as predictors of FEV₁ impairment.Respiratory research · 2026Article
- Quantitative CT Pulmonary Angiography and Echo Cardiography Analysis for Enhanced Cardiovascular Assessment of Right Ventricular Failure in Pulmonary Hypertension.International journal of general medicine · 2026Article
- Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations.Chest · 2024Article
- Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- Pulmonary artery enlargement predicts poor survival in patients with COPD: A meta-analysis.Pulmonary circulation · 2022Article
- Article
- Diagnostic accuracy, sensitivity, and specificity of CT pulmonary artery to aorta diameter ratio in screening for pulmonary hypertension in end-stage COPD patients.Croatian medical journal · 2021Article
- Main pulmonary artery enlargement predicts 90-day readmissions in Chinese COPD patients.Journal of thoracic disease · 2021Article
- Co-existence of COPD and bronchiectasis: a risk factor for a high ratio of main pulmonary artery to aorta diameter (PA:A) from computed tomography in COPD patients.International journal of chronic obstructive pulmonary disease · 2018Article
- Characterization of lymphangioleiomyomatosis patients with discordance between spirometric and diffusion measurements of pulmonary function.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- CT measurements of central pulmonary vasculature as predictors of severe exacerbation in COPD.Medicine · 2018Article
- In Rotterdam, size really does matter: implications of pulmonary artery enlargement on mortality.The European respiratory journal · 2017Article
- A comprehensive analysis of association of medical history with airflow limitation: a cross-sectional study.International journal of chronic obstructive pulmonary disease · 2017Article
- Usefulness of the desaturation-distance ratio from the six-minute walk test for patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Article
- Pulmonary artery enlargement and cystic fibrosis pulmonary exacerbations: a cohort study.The Lancet. Respiratory medicine · 2016Article
- Implications of the pulmonary artery to ascending aortic ratio in patients with relatively mild chronic obstructive pulmonary disease.Journal of thoracic disease · 2016Article
- Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province.Journal of genetics · 2016Article
- A semi-automatic framework of measuring pulmonary arterial metrics at anatomic airway locations using CT imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is a complex condition defined by progressive airflow limitation in response to noxious stimuli, inflammation, and vascular changes. COPD exacerbations are critical events in the natural history of the disease, accounting for the majority of disease burden, cost, and mortality. Pulmonary vascular disease is an important risk factor for disease progression and exacerbation risk. Relative pulmonary artery enlargement on computed tomography scan, defined by a pulmonary artery to aortic (PA:A) ratio >1, has been evaluated as a marker of pulmonary vascular disease. The PA:A ratio can be measured reliably independent of electrocardiographic gating or the use of contrast, and in healthy patients a PA:A ratio >0.9 is considered to be abnormal. The PA:A ratio has been compared with invasive hemodynamic parameters, primarily mean pulmonary artery pressure in various disease conditions and is more strongly correlated with mean pulmonary artery pressure in obstructive as compared with interstitial lung disease. In patients without known cardiac or pulmonary disease, the PA:A ratio is predictive of mortality, while in COPD, an elevated PA:A ratio is correlated with increased exacerbation risk, outperforming other well established predictors of these events. Future studies should be aimed at determining the stability of the metric over time and evaluating the utility of the PA:A ratio in guiding specific therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.