Evidence map›Paper›PMID 24235292›Full record

ArticleIEEE transactions on bio-medical engineering2014

Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models.

Brent Foster, Ulas Bagci, Ziyue Xu, Bappaditya Dey, Brian Luna, William Bishai, Sanjay Jain, Daniel J Mollura

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 64 citations in OpenAlex.

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  6. Implications of the Harmonization of [Tomography (Ann Arbor, Mich.) · 2022
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  9. Quantitative Analysis of Heterogeneous [Molecular imaging and biology · 2019
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  11. Joint Tumor Segmentation in PET-CT Images Using Co-Clustering and Fusion Based on Belief Functions.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2019
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Primary lung tumor segmentation from PET-CT volumes with spatial-topological constraint.International journal of computer assisted radiology and surgery · 2016
    Article
  17. Article
  18. Review
  19. Segmentation based denoising of PET images: an iterative approach via regional means and affinity propagation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Brent Foster
Ulas Bagci
Ziyue Xu
Bappaditya Dey
Brian Luna
William Bishai
Sanjay Jain
Daniel J Mollura
National Institutes of Health · USJohns Hopkins University · USJohns Hopkins Medicine · US

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Novel imaging biomarkers to address fundamental controversies in TB pathogenesisDP2OD006492 · OD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2014
$2.9M
PK/PD Evaluation Resistance Development in Caseating GranulomaR01AI079590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2008 to 2011
$2.5M
Computer-Aided Detection for Infectious Disease ImagingZIACL090018 · CLC · CLINICAL CENTER · PI MOLLURA, DANIEL · 2010 to 2018
$0k
Howard Hughes Medical InstituteIntramural NIH HHS Z99 CL999999Intramural NIH HHS ZIA CL090018NIAID NIH HHS R01 AI079590NIAID NIH HHS R01AI079590NIGMS NIH HHS T32 GM008752NIH HHS DP2 OD006492NIH HHS OD006492PHS HHS R01A1035272
6 · The paper itself

Abstract

Pulmonary infections often cause spatially diffuse and multi-focal radiotracer uptake in positron emission tomography (PET) images, which makes accurate quantification of the disease extent challenging. Image segmentation plays a vital role in quantifying uptake due to the distributed nature of immuno-pathology and associated metabolic activities in pulmonary infection, specifically tuberculosis (TB). For this task, thresholding-based segmentation methods may be better suited over other methods; however, performance of the thresholding-based methods depend on the selection of thresholding parameters, which are often suboptimal. Several optimal thresholding techniques have been proposed in the literature, but there is currently no consensus on how to determine the optimal threshold for precise identification of spatially diffuse and multi-focal radiotracer uptake. In this study, we propose a method to select optimal thresholding levels by utilizing a novel intensity affinity metric within the affinity propagation clustering framework. We tested the proposed method against 70 longitudinal PET images of rabbits infected with TB. The overall dice similarity coefficient between the segmentation from the proposed method and two expert segmentations was found to be 91.25 ±8.01% with a sensitivity of 88.80 ±12.59% and a specificity of 96.01 ±9.20%. High accuracy and heightened efficiency of our proposed method, as compared to other PET image segmentation methods, were reported with various quantification metrics.

Indexed as

AlgorithmsAnimalsDisease Models, AnimalImage Processing, Computer-AssistedPositron-Emission TomographyRabbitsReproducibility of ResultsSensitivity and SpecificityTuberculosis

Identifiers

PMID24235292
PMCPMC4196700
OpenAlexW2008411978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.