ArticleInvestigative ophthalmology & visual science2013
The influence of genetic background on conventional outflow facility in mice.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Control values of intraocular pressure in different species: a review of literature.Croatian medical journal · 2024Review
- Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway.Investigative ophthalmology & visual science · 2022Article
- Measurement of postmortem outflow facility using iPerfusion.Experimental eye research · 2022Article
- Longitudinal outcomes of circumlimbal suture model-induced chronic ocular hypertension in Sprague-Dawley albino rats.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure.Scientific reports · 2020Article
- Secreted protein acidic and rich in cysteine (SPARC) knockout mice have greater outflow facility.PloS one · 2020Article
- Reduced humidity experienced by mice in vivo coincides with reduced outflow facility measured ex vivo.Experimental eye research · 2019Article
- Aqueous Humor Dynamics of the Brown-Norway Rat.Investigative ophthalmology & visual science · 2018Article
- The relationship between outflow resistance and trabecular meshwork stiffness in mice.Scientific reports · 2018Article
- Direct measurement of pressure-independent aqueous humour flow using iPerfusion.Experimental eye research · 2017Article
- Pigmented and albino rats differ in their responses to moderate, acute and reversible intraocular pressure elevation.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Trabecular meshwork stiffness in glaucoma.Experimental eye research · 2017Review
- Unconventional aqueous humor outflow: A review.Experimental eye research · 2017Review
- Measurement of Outflow Facility Using iPerfusion.PloS one · 2016Article
- Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice.Molecular vision · 2016Article
- Physical Factors Affecting Outflow Facility Measurements in Mice.Investigative ophthalmology & visual science · 2015Article
- Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Experimental eye research · 2015Review
- High-throughput screening for modulators of cellular contractile force.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Role of nitric oxide in murine conventional outflow physiology.American journal of physiology. Cell physiology · 2015Article
- Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma.Current ophthalmology reports · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeIntraocular pressure (IOP) varies between genetically distinct strains of mice. The purpose was to test the hypothesis that strain-dependent differences in IOP are attributable to differences in conventional outflow facility (C).
methodsThe IOP was measured by rebound tonometry in conscious or anesthetized BALB/cJ, C57BL/6J, and CBA/J mice (N = 6-10 per strain). Conventional outflow facility was measured by ex vivo perfusion of enucleated eyes (N = 9-10 per strain).
resultsConscious IOP varied between strains, being highest in CBA/J (14.5 ± 0.9 mm Hg, mean ± SD), intermediate in C57BL/6J (12.3 ± 1.0 mm Hg), and lowest in BALB/cJ (10.6 ± 1.8 mm Hg) mice. Anesthesia reduced IOP and eliminated any detectable differences between strains. Conventional outflow facility also varied between strains, but, in contrast to IOP, C was lowest in CBA/J (0.0113 ± 0.0031 μL/min/mm Hg) and highest in BALB/cJ (0.0164 ± 0.0059 μL/min/mm Hg). Like IOP, C was intermediate in C57BL/6J (0.0147 ± 0.0029 μL/min/mm Hg). There was a strong correlation between conscious IOP and outflow resistance (1/C) from individual eyes across all three strains, revealing that 70% of the variation in IOP was attributable to variation in outflow resistance.
conclusionsDifferences in IOP among three genetically distinct murine strains are attributable largely to differences in conventional outflow facility. These results motivate further studies using mice to identify the morphologic and genetic factors that underlie IOP regulation within the conventional outflow pathway.
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