Evidence map›Paper›PMID 24234439›Full record

ArticleNucleic acids research2014

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands.

Adam J Pawson, Joanna L Sharman, Helen E Benson, Elena Faccenda, Stephen P H Alexander, O Peter Buneman, Anthony P Davenport, John C McGrath, John A Peters, Christopher Southan and 4 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 748 papers.

0numbers the graph read from it
0cells of the map it votes in
748citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

748 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. The IUPHAR/BPS Guide to PHARMACOLOGY in 2026.Nucleic acids research · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Network Medicine: A Potential Approach for Virtual Drug Screening.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  12. Article
  13. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024.Nucleic acids research · 2024
    Article
  14. Article
  15. Review
  16. Nicotine: From Discovery to Biological Effects.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article

688 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Adam J PawsonThe University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK, School of Biomedical Sciences, Life Sciences E Floor, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK, Laboratory for Foundations of Computer Science, School of Informatics, 10 Crichton Street, University of Edinburgh, Edinburgh EH8 9AB, UK, Clinical Pharmacology Unit, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK, School of Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK, Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK and Spedding Research Solutions SARL, 6 Rue Ampere, Le Vésinet 78110, France.
Joanna L Sharman
Helen E Benson
Elena Faccenda
Stephen P H Alexander
O Peter Buneman
Anthony P Davenport
John C McGrath
John A Peters
Christopher Southan
Michael Spedding
Wenyuan Yu
Anthony J Harmar
NC-IUPHAR

Funding

Wellcome Trust 099156
6 · The paper itself

Abstract

The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the ∼6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques.

Indexed as

Databases, ChemicalDrug DiscoveryInternetKnowledge BasesLigandsPharmaceutical PreparationsProteinsLigandsPharmaceutical PreparationsProteins

Identifiers

PMID24234439
PMCPMC3965070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.