ArticleCell death & disease2013
miR-24 affects hair follicle morphogenesis targeting Tcf-3.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed.
- Hair Follicles as Micro-Organs: MicroRNA-Mediated Control of Growth, Cycling, and Fiber Traits.Biomolecules · 2026Review
- Emerging biomedical engineering strategies for hair follicle regeneration.Bioactive materials · 2025Review
- MiRNA-24 downregulates KLF6 affecting STAT3 protein expression and phosphorylation regulating melanogenesis in cashmere goat coat.Animal bioscience · 2025Article
- Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment.Pharmaceutics · 2024Article
- Identification of Potential miRNA-mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer.Animals : an open access journal from MDPI · 2023Article
- Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats' Follicle Development Assessed by Whole-Transcriptome Sequencing Technology.Animals : an open access journal from MDPI · 2023Article
- Article
- Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth.International journal of molecular sciences · 2023Article
- Regulation of secondary hair follicle cycle in cashmere goats by miR-877-3p targeting IGFBP5 gene.Journal of animal science · 2023Article
- Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells.Nutrients · 2022Article
- Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development.BMC genomics · 2022Article
- Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis.Biomolecules · 2022Article
- Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles.Frontiers in cell and developmental biology · 2022Review
- Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls.Bioengineering & translational medicine · 2022Review
- CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression.Archives animal breeding · 2022Article
- Versatile role of miR-24/24-1*/24-2* expression in cancer and other human diseases.American journal of translational research · 2022Review
- Review
- Chi-miR-370-3p regulates hair follicle morphogenesis of Inner Mongolian cashmere goats.G3 (Bethesda, Md.) · 2021Article
- Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.Experimental dermatology · 2021Review
- The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
During embryonic development, hair follicles (HFs) develop from an epidermal-mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.