ArticleJAMA otolaryngology-- head & neck surgery2014
Treatment of severe porcine tracheomalacia with a 3-dimensionally printed, bioresorbable, external airway splint.
Article in JAMA otolaryngology-- head & neck surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- New frontiers and emerging applications of 3D printing in ENT surgery: a systematic review of the literature.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Pooled it
- 3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models.Nature communications · 2026Article
- Degradation and Fatigue Behavior of 3D-Printed Bioresorbable Tracheal Splints.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- 3D printing modality effect: Distinct printing outcomes dependent on selective laser sintering (SLS) and melt extrusion.Journal of biomedical materials research. Part A · 2024Article
- Enhancement of tracheal cartilage regeneration by local controlled release of stromal cell-derived factor 1α with gelatin hydrogels and systemic administration of high-mobility group box 1 peptide.Regenerative therapy · 2024Article
- Robot-Assisted Correction of a Supra-Long Tracheal Stenosis Using C-Type Nickel-Titanium Alloy Exterior Stenting and Suspension Fixation Technique: A Case Report.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024Article
- A novel ex vivo tracheobronchomalacia model for airway stent testing and in vivo model refinement.The Journal of thoracic and cardiovascular surgery · 2023Article
- Innovation in rigid bronchoscopy-past, present, and future.Journal of thoracic disease · 2023Review
- Three Dimensional Printing and Its Applications Focusing on Microneedles for Drug Delivery.Pharmaceutics · 2023Review
- Current Status and Future Outlook of Additive Manufacturing Technologies for the Reconstruction of the Trachea.Journal of functional biomaterials · 2023Review
- Novel Therapy for Acquired Tracheomalacia with a Tissue-Engineered Extraluminal Tracheal Splint and Autologous Mesenchymal-Derived Chondrocytes.International archives of otorhinolaryngology · 2023Article
- Bioengineering and Clinical Translation of Human Lung and its Components.Advanced biology · 2023Review
- Mathematical surface function-based design and 3D printing of airway stents.3D printing in medicine · 2022Article
- 3D Printing-A Cutting Edge Technology for Treating Post-Infarction Patients.Life (Basel, Switzerland) · 2021Review
- Motility Improvement of Biomimetic Trachea Scaffold via Hybrid 3D-Bioprinting Technology.Polymers · 2021Article
- A Two-Scale Multi-Resolution Topologically Optimized Multi-Material Design of 3D Printed Craniofacial Bone Implants.Micromachines · 2021Article
- Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics.Clinical, cosmetic and investigational dermatology · 2020Review
- Progressive 3D Printing Technology and Its Application in Medical Materials.Frontiers in pharmacology · 2020Review
- The Fabrication andFrontiers in bioengineering and biotechnology · 2020Article
- Preclinical assessment of resorbable silk splints for the treatment of pediatric tracheomalacia.The Laryngoscope · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
importanceThe study demonstrates use of a novel intervention for severe tracheobronchomalacia (TBM).
objectiveTo test a novel, 3-dimensionally (3D) printed, bioresorbable airway splint for efficacy in extending survival in a porcine model of severe, life-threatening TBM. DESIGN AND
participantsA randomized, prospective animal trial was used to evaluate an external airway splint as treatment of severe, life-threatening TBM in a multi-institutional, multidisciplinary collaboration between a biomedical engineering department and an academic animal surgery center. Six 2-month-old Yorkshire pigs underwent tracheal cartilage division and inner tracheal lumen dissociation and were randomly assigned to splint treatment (n = 3) or control groups (n = 3). Two additional pigs had the splint placed over their normal trachea.
interventionsA 3D-printed, bioresorbable airway splint was assessed in a porcine animal model of life-threatening TBM. The open-cylindrical, bellow-shaped, porous polycaprolactone splint was placed externally and designed to suspend the underlying collapsed airway. Two additional animals were splinted without model creation. MAIN OUTCOMES AND MEASURES: The observer-based Westley Clinical Croup Scale was used to assess the clinical condition of animals postoperatively. Animal survival time was noted.
resultsComplete or nearly complete tracheal lumen collapse was observed in each animal, with resolution of symptoms in all of the experimental animals after splint placement. Using our severe TBM animal model, survival was significantly longer in the experimental group receiving the airway splint after model creation than in the control group (P = .0495). CONCLUSIONS AND RELEVANCE: A multidisciplinary effort producing a computer-aided designed, computer-aided manufactured bioresorbable tracheobronchial splint was tested in a porcine model of severe TBM and was found to extend survival time. Mortality in the splinted group was ascribed to the TBM model based on the lack of respiratory distress in splinted pigs, long-term survival in animals implanted with the splint without TBM, and necropsy findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.