ArticleAJNR. American journal of neuroradiology2014
Mind the gap: impact of computational fluid dynamics solution strategy on prediction of intracranial aneurysm hemodynamics and rupture status indicators.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed.
- Improving Risk Stratification and Surgical Decision-Making for Unruptured Cerebral Aneurysm: A Proof-of-Concept of Novel Morphological Parameters and Computational Hemodynamics.Brain sciences · 2026Article
- Patient-Specific Hemodynamic Simulation for Predicting Stroke Laterality in Cardiac Embolism.Journal of stroke · 2026Article
- Comparative Analysis of Open-Source Finite Element Method Solvers for Computational Fluid Dynamics Performance in a Carotid Artery Model.Journal of biomechanical engineering · 2026Article
- On the Numerical Evaluation of Wall Shear Stress Using the Finite Element Method.International journal for numerical methods in biomedical engineering · 2025Article
- Heterogeneous model to evaluate CFD in intracranial bifurcation aneurysms treated with the WEB device to predict angiographic outcome.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Geometry of intracranial aneurysms and of intrasaccular devices may influence aneurysmal occlusion rates after endovascular treatment.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Improving Prediction of Intracranial Aneurysm Rupture Status Using Temporal Velocity-Informatics.Annals of biomedical engineering · 2025Article
- Fast simulation of hemodynamics in intracranial aneurysms for clinical use.Acta neurochirurgica · 2025Article
- Computational fluid dynamics modelling of hemodynamics in aortic aneurysm and dissection: a review.Frontiers in bioengineering and biotechnology · 2025Review
- On flow fluctuations in ruptured and unruptured intracranial aneurysms: resolved numerical study.Scientific reports · 2024Article
- Flow-induced high frequency vascular wall vibrations in an arteriovenous fistula: a specific stimulus for stenosis development?Physical and engineering sciences in medicine · 2024Article
- Understanding intracranial aneurysm sounds via high-fidelity fluid-structure-interaction modelling.Communications medicine · 2023Article
- Is Accurate Lumen Segmentation More Important than Outlet Boundary Condition in Image-Based Blood Flow Simulations for Intracranial Aneurysms?Cardiovascular engineering and technology · 2023Article
- Onset and nature of flow-induced vibrations in cerebral aneurysms via fluid-structure interaction simulations.Biomechanics and modeling in mechanobiology · 2023Article
- Aneurysm Neck Overestimation has a Relatively Modest Impact on Simulated Hemodynamics.Cardiovascular engineering and technology · 2023Article
- Accelerated sequences of 4D flow MRI using GRAPPA and compressed sensing: A comparison against conventional MRI and computational fluid dynamics.Magnetic resonance in medicine · 2022Article
- Integrating computational fluid dynamics data into medical image visualization workflows via DICOM.International journal of computer assisted radiology and surgery · 2022Article
- Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases.Frontiers in bioengineering and biotechnology · 2022Review
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- Spectral Decomposition of the Flow and Characterization of the Sound Signals through Stenoses with Different Levels of Severity.Bioengineering (Basel, Switzerland) · 2021Article
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Abstract
background and purposeComputational fluid dynamics has become a popular tool for studying intracranial aneurysm hemodynamics, demonstrating success for retrospectively discriminating rupture status; however, recent highly refined simulations suggest potential deficiencies in solution strategies normally used in the aneurysm computational fluid dynamics literature. The purpose of the present study was to determine the impact of this gap. MATERIALS AND
methodsPulsatile flow in 12 realistic MCA aneurysms was simulated by using both high-resolution and normal-resolution strategies. Velocity fields were compared at selected instants via domain-averaged error. We also compared wall shear stress fields and various reduced hemodynamic indices: cycle-averaged mean and maximum wall shear stress, oscillatory shear index, low shear area, viscous dissipation ratio, and kinetic energy ratio.
resultsInstantaneous differences in flow and wall shear stress patterns were appreciable, especially for bifurcation aneurysms. Linear regressions revealed strong correlations (R(2) > 0.9) between high-resolution and normal-resolution solutions for all indices except kinetic energy ratio (R(2) = 0.25) and oscillatory shear index (R(2) = 0.23); however, for most indices, the slopes were significantly <1, reflecting a pronounced underestimation by the normal-resolution simulations. Some high-resolution simulations were highly unstable, with fluctuating wall shear stresses reflected by the poor oscillatory shear index correlation.
conclusionsTypical computational fluid dynamics solution strategies may ultimately be adequate for augmenting rupture risk assessment on the basis of certain highly reduced indices; however, they cannot be relied on for predicting the magnitude and character of the complex biomechanical stimuli to which the aneurysm wall may be exposed. This impact of the computational fluid dynamics solution strategy is likely greater than that for other modeling assumptions or uncertainties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.