ArticleJournal of biomechanical engineering2013
Localization of viscous behavior and shear energy dissipation in articular cartilage under dynamic shear loading.
Article in Journal of biomechanical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2019Pooled it
- Shear Strain Stiffening in Cartilage is Governed by a Mechanical Phase Transition.bioRxiv : the preprint server for biology · 2026Article
- Local shear properties of rabbit articular cartilage capture surface region mechanics of human, equine, and bovine tissue.Journal of biomechanics · 2025Article
- Modeling Fatigue Failure of Cartilage and Fibrous Biological Tissues Using Constrained Reactive Mixture Theory.Journal of biomechanical engineering · 2024Article
- Outcomes of Osteochondral Autologous Transplantation with Ipsilateral Lateral Talar Autograft for Medial Osteochondral Lesions of the Talus.Clinics in orthopedic surgery · 2024Article
- Structural origins of cartilage shear mechanics.Science advances · 2022Article
- Cartilage articulation exacerbates chondrocyte damage and death after impact injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Comparative Tribology: Articulation-induced rehydration of cartilage across species.Biotribology (Oxford) · 2021Article
- Individualized Characterization of the Distribution of Collagen Fibril Dispersion Using Optical Aberrations of the Cornea for Biomechanical Models.Investigative ophthalmology & visual science · 2020Article
- Surgical osteochondral defect repair in the horse-a matter of form or function?Equine veterinary journal · 2020Review
- Effect of whole body vibration on HIF-2α expression in SD rats with early knee osteoarthritis.Journal of bone and mineral metabolism · 2020Article
- Immature bovine cartilage wear by fatigue failure and delamination.Journal of biomechanics · 2020Article
- Apparatus and Method for Rapid Detection of Acoustic Anisotropy in Cartilage.Journal of medical and biological engineering · 2020Article
- Mitoprotective therapy prevents rapid, strain-dependent mitochondrial dysfunction after articular cartilage injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Vulnerability of corneal endothelial cells to mechanical trauma from indentation forces assessed using contact mechanics and fluorescence microscopy.Experimental eye research · 2018Article
- Physiology and Engineering of the Graded Interfaces of Musculoskeletal Junctions.Annual review of biomedical engineering · 2018Review
- Local and global measurements show that damage initiation in articular cartilage is inhibited by the surface layer and has significant rate dependence.Journal of biomechanics · 2018Article
- An Alternative Method to Characterize the Quasi-Static, Nonlinear Material Properties of Murine Articular Cartilage.Journal of biomechanical engineering · 2018Article
- Mechanical function near defects in an aligned nanofiber composite is preserved by inclusion of disorganized layers: Insight into meniscus structure and function.Acta biomaterialia · 2017Article
- Nanoscale physicochemical properties of chain- and step-growth polymerized PEG hydrogels affect cell-material interactions.Journal of biomedical materials research. Part A · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Though remarkably robust, articular cartilage becomes susceptible to damage at high loading rates, particularly under shear. While several studies have measured the local static and steady-state shear properties of cartilage, it is the local viscoelastic properties that determine the tissue's ability to withstand physiological loading regimens. However, measuring local viscoelastic properties requires overcoming technical challenges that include resolving strain fields in both space and time and accurately calculating their phase offsets. This study combined recently developed high-speed confocal imaging techniques with three approaches for analyzing time- and location-dependent mechanical data to measure the depth-dependent dynamic modulus and phase angles of articular cartilage. For sinusoidal shear at frequencies f = 0.01 to 1 Hz with no strain offset, the dynamic shear modulus |G*| and phase angle δ reached their minimum and maximum values (respectively) approximately 100 μm below the articular surface, resulting in a profound focusing of energy dissipation in this narrow band of tissue that increased with frequency. This region, known as the transitional zone, was previously thought to simply connect surface and deeper tissue regions. Within 250 μm of the articular surface, |G*| increased from 0.32 ± 0.08 to 0.42 ± 0.08 MPa across the five frequencies tested, while δ decreased from 12 deg ± 1 deg to 9.1 deg ± 0.5 deg. Deeper into the tissue, |G*| increased from 1.5 ± 0.4 MPa to 2.1 ± 0.6 MPa and δ decreased from 13 deg ± 1 deg to 5.5 deg ± 0.2 deg. Viscoelastic properties were also strain-dependent, with localized energy dissipation suppressed at higher shear strain offsets. These results suggest a critical role for the transitional zone in dissipating energy, representing a possible shift in our understanding of cartilage mechanical function. Further, they give insight into how focal degeneration and mechanical trauma could lead to sustained damage in this tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.