ArticleJournal of the American Heart Association2013
Preliminary biomarkers for identification of human ascending thoracic aortic aneurysm.
Article in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Is There Enough Evidence to Support the Role of Glycosaminoglycans and Proteoglycans in Thoracic Aortic Aneurysm and Dissection?-A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Circulating type I collagen pro-α1 chain is inversely associated with the presence of coronary atherosclerosis in a Swedish middle-aged population.Scientific reports · 2026Article
- Differential Expression Analyses on Human Aortic Tissue Reveal Novel Genes and Pathways Associated With Abdominal Aortic Aneurysm Onset and Progression.Journal of the American Heart Association · 2024Article
- Wall shear stress measured with 4D flow CMR correlates with biomarkers of inflammation and collagen synthesis in mild-to-moderate ascending aortic dilation and tricuspid aortic valves.European heart journal. Cardiovascular Imaging · 2024Article
- New Directions in Diagnostics for Aortic Aneurysms: Biomarkers and Machine Learning.Journal of clinical medicine · 2024Review
- The role of transforming growth factor beta in bicuspid aortic valve aortopathy.Indian journal of thoracic and cardiovascular surgery · 2023Article
- Multi-omics in thoracic aortic aneurysm: the complex road to the simplification.Cell & bioscience · 2023Review
- Non-syndromic thoracic aortic aneurysm: cellular and molecular insights.The Journal of pathology · 2021Review
- Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms.Cell reports. Medicine · 2021Article
- New indicators for systematic assessment of aortic morphology: a narrative review.Journal of thoracic disease · 2021Review
- Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease.Journal of cardiovascular development and disease · 2019Article
- Is there a role for biomarkers in thoracic aortic aneurysm disease?General thoracic and cardiovascular surgery · 2019Review
- Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy?Frontiers in physiology · 2019Article
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Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHuman ascending thoracic aortic aneurysms (ATAAs) are life threatening and constitute a leading cause of mortality in the United States. Previously, we demonstrated that collagens α2(V) and α1(XI) mRNA and protein expression levels are significantly increased in ATAAs. METHODS AND
resultsIn this report, the authors extended these preliminary studies using high-throughput proteomic analysis to identify additional biomarkers for use in whole blood real-time RT-PCR analysis to allow for the identification of ATAAs before dissection or rupture. Human ATAA samples were obtained from male and female patients aged 65 ± 14 years. Both bicuspid and tricuspid aortic valve patients were included and compared with nonaneurysmal aortas (mean diameter 2.3 cm). Five biomarkers were identified as being suitable for detection and identification of ATAAs using qRT-PCR analysis of whole blood. Analysis of 41 samples (19 small, 13 medium-sized, and 9 large ATAAs) demonstrated the overexpression of 3 of these transcript biomarkers correctly identified 79.4% of patients with ATAA of ≥4.0 cm (P<0.001, sensitivity 0.79, CI=0.62 to 0.91; specificity 1.00, 95% CI=0.42 to 1.00).
conclusionA preliminary transcript biomarker panel for the identification of ATAAs using whole blood qRT-PCR analysis in men and women is presented.
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