ReviewTrends in cell biology2014
Guest list or black list: heritable small RNAs as immunogenic memories.
Review in Trends in cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model.Entropy (Basel, Switzerland) · 2023Article
- Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD).Current pharmaceutical design · 2021Article
- Transgenerational fitness effects of lifespan extension by dietary restriction inProceedings. Biological sciences · 2021Article
- Evolution of plasticity in production and transgenerational inheritance of small RNAs under dynamic environmental conditions.PLoS genetics · 2021Article
- tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism model.RNA biology · 2020Article
- Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces.Life (Basel, Switzerland) · 2020Article
- H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes.eLife · 2019Article
- RNA interference-based antiviral immune response against the salivary gland hypertrophy virus in Glossina pallidipes.BMC microbiology · 2018Article
- Use/disuse paradigms are ubiquitous concepts in characterizing the process of inheritance.RNA biology · 2017Review
- Abiotic stress miRNomes in the Triticeae.Functional & integrative genomics · 2017Review
- Putative RNA-directed adaptive mutations in cancer evolution.Transcription · 2016Article
- Vertically- and horizontally-transmitted memories - the fading boundaries between regeneration and inheritance in planaria.Biology open · 2016Review
- Why are individuals so different from each other?Heredity · 2015Review
- The Lamarckian chicken and the Darwinian egg.Biology direct · 2015Article
- Immunity, suicide or both? Ecological determinants for the combined evolution of anti-pathogen defense systems.BMC evolutionary biology · 2015Article
- Calorie restriction à Lamarck.Cell · 2014Article
- Article
- Pseudo-chaotic oscillations in CRISPR-virus coevolution predicted by bifurcation analysis.Biology direct · 2014Article
- Non-coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life.The Journal of physiology · 2014Review
- The soft genome.WormArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Small RNA-mediated gene silencing plays a pivotal role in genome immunity by recognizing and eliminating viruses and transposons that may otherwise colonize the genome. However, individual genomic parasites are highly diverse and employ multiple immune-evasion techniques, making this silencing challenging. Here I review a new theory proposing that the integrity of the germline is maintained by transgenerationally transmitted RNA 'memories' that record ancestral gene expression patterns and delineate 'self' from 'foreign' sequences. To maintain such recollection, two tactics are employed in parallel: 'black listing' of invading nucleic acids and 'guest listing' of endogenous genes. Studies in several organisms have shown that this memorization is used by the next generation of small RNAs to act as 'inherited vaccines' that attack invading elements or as 'inherited licenses' that permit the transcription of autogenous sequences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.