ArticleJournal of leukocyte biology2014
Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors.
Article in Journal of leukocyte biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Chromatin landscape alteration uncovers multiple transcriptional circuits during memory CD8+ T-cell differentiation.Protein & cell · 2025Article
- Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration and Th17 Pathogenicity.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- STAT4 increases the phenotypic and functional heterogeneity of intestinal tissue-resident memory T cells.Mucosal immunology · 2023Article
- CD8 T Cell Vaccines and a Cytomegalovirus-Based Vector Approach.Life (Basel, Switzerland) · 2021Review
- Memory T-Cell Heterogeneity and Terminology.Cold Spring Harbor perspectives in biology · 2021Review
- Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.The Journal of experimental medicine · 2021Article
- Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Heterogenous Populations of Tissue-Resident CD8Immunity · 2020Article
- Memory CD4Cells · 2020Review
- MicroRNA regulation of CD8Non-coding RNA investigation · 2019Article
- Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.The Journal of experimental medicine · 2015Article
- Human memory, but not naive, CD4+ T cells expressing transcription factor T-bet might drive rapid cytokine production.The Journal of biological chemistry · 2014Article
- Molecular regulation of effector and memory T cell differentiation.Nature immunology · 2014Review
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5 authors at 1 institution in 1 country.
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Abstract
Effector and memory CD4 and CD8 T cell responses are critical for the control of many intracellular pathogens. The development of these populations is governed by transcription factors that molecularly control their differentiation, function, and maintenance. Two transcription factors known to be involved in these processes are Tbet and STAT4. Although Tbet has been shown to regulate CD8 T cell fate decisions and effector CD4 T cell choices, the contribution of STAT4 is less well understood. To address this, we examined the impact of STAT4 on T cell responses in the presence or absence of Tbet, following LCMV infection by using mice lacking Tbet, STAT4, or both transcription factors. STAT4 was not required for Tbet or Eomes expression; however, virus-specific effector CD8 T cells are skewed toward a memory-precursor phenotype in the absence of STAT4. This altered proportion of memory precursors did not result in an increase in memory CD8 T cells after the resolution of the infection. We also demonstrate that virus-specific effector and memory CD4 T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 T cells was apparent in mice lacking both transcription factors. Collectively, we have discovered distinct roles for Tbet and STAT4 in shaping the phenotype and function of virus-specific T cell responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.