ArticleThe Journal of infectious diseases2014
The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 564 papers, 4 of them syntheses that pooled it.
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Who cites it
564 citing papers in PubMed, 4 syntheses or guidelines pooled it, 927 citations in OpenAlex.
- Cytokine Indicators Associated with Disease Severity in Severe Fever with Thrombocytopenia Syndrome: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2026Pooled it
- A meta-analysis-informed diagnostic stratification tool for invasive pulmonary aspergillosis in severe fever with thrombocytopenia syndrome: systematic review, meta-analysis, and single-center cohort-based assessment.Frontiers in cellular and infection microbiology · 2026Pooled it
- Diversity and transmission and zoonotic potential of microbes in true insectivores.Nature communications · 2025Pooled it
- Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Dissecting the evolutionary forces shaping codon usage bias in SFTSV from eastern China: Insights from a previously underrepresented region.Virulence · 2026Article
- First autochthonous case of severe fever with thrombocytopenia syndrome in Hokkaido, the northernmost island of Japan.IJID regions · 2026Article
- Meteorological and environmental factors associated with the spatiotemporal risk of severe fever with thrombocytopenia syndrome in Japan: A prefecture-level time-series modeling study.One health (Amsterdam, Netherlands) · 2026Article
- Interplay between SFTSV and host innate immunity: Viral evasion mechanisms, pathogenesis, and therapeutic perspectives.iScience · 2026Review
- Phylogeographic epidemiology of Dabie bandavirus in East Asia: divergent transmission networks and genotype‑linked clinical severity.Infectious diseases of poverty · 2026Article
- From qualitative prediction to quantitative insight: combined meteorological patterns and regional dynamics of severe fever with thrombocytopenia syndrome in Liaoning Province, China, 2010-2024.Infectious Disease Modelling · 2026Article
- Differential immune responses to SFTSV Gn and Gc mRNA vaccines in mice and dogs.Microbiology spectrum · 2026Article
- Effectiveness of lignans against severe fever with thrombocytopenia syndrome virus infection.Virologica Sinica · 2026Article
- Comparison of the pathogenicity in type I interferon receptor deficient A129 mice and characterization of amino acid substitutions among severe fever with thrombocytopenia syndrome virus strains.The Journal of veterinary medical science · 2026Article
- All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in mice.Nature microbiology · 2026Article
- Epidemiological characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China, 2010-2024: a fifteen-year national surveillance analysis.BMC infectious diseases · 2026Article
- Serological and molecular assessment of severe fever with thrombocytopenia syndrome virus infection in wild boars from two adjacent endemic prefectures in Japan.The Journal of veterinary medical science · 2026Article
- Association between serum calcium and in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study.Virology journal · 2026Article
- Whole-body CT characteristics of patients with severe fever with thrombocytopenia syndrome.Japanese journal of radiology · 2026Article
- Temperature-dependent infectious stability of Severe fever with thrombocytopenia syndrome virus.The Journal of veterinary medical science · 2026Article
- Geographic variability of severe fever with thrombocytopenia syndrome virus genomes in the Miyazaki Prefecture, Japan: a cross-sectional molecular epidemiological study.Parasites & vectors · 2026Article
504 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
50 authors at 13 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan.
methodsVirologic and pathologic examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification and/or the detection of anti-SFTSV immunoglobulin G antibody in sera. Physicians were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS.
resultsA female patient who died in 2012 received a diagnosis of SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged ≥50 years and lived in western Japan. Six cases were fatal. The ratio of males to females was 8:3. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis.
conclusionsSFTS has been endemic to Japan, and SFTSV has been circulating naturally within the country.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.