ArticleDevelopmental cell2013
Tip cells act as dynamic cellular anchors in the morphogenesis of looped renal tubules in Drosophila.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Insights into human kidney function from the study of Drosophila.Pediatric nephrology (Berlin, Germany) · 2023Review
- Insights and perspectives on the enigmatic alary muscles of arthropods.Frontiers in cell and developmental biology · 2023Review
- Early patterning followed by tissue growth establishes distal identity inFrontiers in cell and developmental biology · 2022Article
- Extracellular matrix dynamics in tubulogenesis.Cellular signalling · 2020Review
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Article
- Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development.Developmental biology · 2016Article
- Epidermal growth factor signalling controls myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis.PLoS biology · 2014Article
- Tip cells: master regulators of tubulogenesis?Seminars in cell & developmental biology · 2014Review
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Abstract
Tissue morphogenesis involves both the sculpting of tissue shape and the positioning of tissues relative to one another in the body. Using the renal tubules of Drosophila, we show that a specific distal tubule cell regulates both tissue architecture and position in the body cavity. Focusing on the anterior tubules, we demonstrate that tip cells make transient contacts with alary muscles at abdominal segment boundaries, moving progressively forward as convergent extension movements lengthen the tubule. Tip cell anchorage antagonizes forward-directed, TGF-β-guided tubule elongation, thereby ensuring the looped morphology characteristic of renal tubules from worms to humans. Distinctive tip cell exploratory behavior, adhesion, and basement membrane clearing underlie target recognition and dynamic interactions. Defects in these features obliterate tip cell anchorage, producing misshapen and misplaced tubules with impaired physiological function.
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