ArticleDevelopment and psychopathology2013
Premorbid functional development and conversion to psychosis in clinical high-risk youths.
Article in Development and psychopathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Improving Prognostic Accuracy in Subjects at Clinical High Risk for Psychosis: Systematic Review of Predictive Models and Meta-analytical Sequential Testing Simulation.Schizophrenia bulletin · 2017Pooled it
- Negative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-analysis.Harvard review of psychiatryPooled it
- Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.Schizophrenia bulletin · 2026Article
- Psychiatric Antecedents in Adolescents at Clinical High Risk for Psychosis: Insights from the "Parma At-Risk Mental States" Follow-up Program.Research on child and adolescent psychopathology · 2025Article
- Clues from dyadic interactions in early childhood predict psychotic-like experiences at the transition to adolescence in a sample enriched for psychopathology risk.Journal of psychopathology and clinical science · 2025Article
- Automated analysis of clinical interviews indicates altered head movements during social interactions in youth at clinical high-risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Persons at risk for psychosis overestimate social functioning compared to persons with major depressive disorder and community controls.Journal of psychiatric research · 2025Article
- Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion.Schizophrenia bulletin · 2024Article
- Clinical and neurodevelopmental predictors of psychotic disorders in children and adolescents at clinical high risk for psychosis: the CAPRIS study.European child & adolescent psychiatry · 2024Article
- Combinations and Temporal Associations Among Precursor Symptoms Before a First Episode of Psychosis.Schizophrenia bulletin · 2024Article
- GDNF and miRNA-29a as biomarkers in the first episode of psychosis: uncovering associations with psychosocial factors.Frontiers in psychiatry · 2024Article
- Identification of Psychosis Risk and Diagnosis of First-Episode Psychosis: Advice for Clinicians.Psychology research and behavior management · 2024Review
- Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2023Article
- Developmental trajectories of premorbid functioning predict cognitive remediation treatment response in first-episode schizophrenia.Psychological medicine · 2023Article
- Symptoms of Attenuated Psychosis Syndrome in Relatives of Clinical High-Risk Youth: Preliminary Evidence.Schizophrenia bulletin · 2023Article
- Residential instability during adolescence predicts earlier age at onset of psychosis: The moderating role of extraversion.Early intervention in psychiatry · 2023Article
- Psychotic disorders as a framework for precision psychiatry.Nature reviews. Neurology · 2023Review
- The impact of early factors on persistent negative symptoms in youth at clinical high risk for psychosis.Frontiers in psychiatry · 2023Article
- Review of factors resulting in systemic biases in the screening, assessment, and treatment of individuals at clinical high-risk for psychosis in the United States.Frontiers in psychiatry · 2023Review
- Premorbid adjustment associates with cognitive and functional deficits in individuals at ultra-high risk of psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
Abstract
Deterioration in premorbid functioning is a common feature of schizophrenia, but sensitivity to psychosis conversion among clinical high-risk samples has not been examined. This study evaluates premorbid functioning as a predictor of psychosis conversion among a clinical high-risk sample, controlling for effects of prior developmental periods. Participants were 270 clinical high-risk individuals in the North American Prodrome Longitudinal Study-I, 78 of whom converted to psychosis over the next 2.5 years. Social, academic, and total maladjustment in childhood, early adolescence, and late adolescence were rated using the Cannon-Spoor Premorbid Adjustment Scale. Early adolescent social dysfunction significantly predicted conversion to psychosis (hazard ratio = 1.30, p = .014), independently of childhood social maladjustment and independently of severity of most baseline positive and negative prodromal symptoms. Baseline prodromal symptoms of disorganized communication, social anhedonia, suspiciousness, and diminished ideational richness mediated this association. Early adolescent social maladjustment and baseline suspiciousness together demonstrated moderate positive predictive power (59%) and high specificity (92.1%) in predicting conversion. Deterioration of academic and total functioning, although observed, did not predict conversion to psychosis. Results indicate early adolescent social dysfunction to be an important early predictor of conversion. As such, it may be a good candidate for inclusion in prediction algorithms and could represent an advantageous target for early intervention.
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Registered trials
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