ArticleExtreme physiology & medicine2013
Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?
Article in Extreme physiology & medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Fertility Impairment after Trekking at High Altitude: A Proof of Mechanisms on Redox and Metabolic Seminal Changes.International journal of molecular sciences · 2022Article
- Muscle Oxygen Delivery in the Forearm and in theFrontiers in physiology · 2020Article
- Global expression profiling and pathway analysis in two different population groups in relation to high altitude.Functional & integrative genomics · 2019Article
- Population History and Altitude-Related Adaptation in the Sherpa.Frontiers in physiology · 2019Review
- The Smell of Hypoxia: using an electronic nose at altitude and proof of concept of its role in the prediction and diagnosis of acute mountain sickness.Physiological reports · 2018Article
- Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Changes in labial capillary density on ascent to and descent from high altitude.F1000Research · 2016Article
- High altitude-related hypertensive crisis and acute kidney injury in an asymptomatic healthy individual.Extreme physiology & medicine · 2016Article
- Getting the most from venous occlusion plethysmography: proposed methods for the analysis of data with a rest/exercise protocol.Extreme physiology & medicine · 2015Article
- Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia.F1000Research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xtreme Everest 2 (XE2) was part of an ongoing programme of field, laboratory and clinical research focused on human responses to hypoxaemia that was conducted by the Caudwell Xtreme Everest Hypoxia Research Consortium. The aim of XE2 was to characterise acclimatisation to environmental hypoxia during a standardised ascent to high altitude in order to identify biomarkers of adaptation and maladaptation. Ultimately, this may lead to novel diagnostic and treatment strategies for the pathophysiological hypoxaemia and cellular hypoxia observed in critically ill patients. XE2 was unique in comparing participants drawn from two distinct populations: native ancestral high-altitude dwellers (Sherpas) and native lowlanders. Experiments to study the microcirculation, mitochondrial function and the effect that nitric oxide metabolism may exert upon them were focal to the scientific profile. In addition, the genetic and epigenetic (methylation and histone modification) basis of observed differences in phenotype was explored. The biological samples and phenotypic metadata already collected during XE2 will be analysed as an independent study. Data generated will also contribute to (and be compared with) the bioresource obtained from our previous observational high-altitude study, Caudwell Xtreme Everest (2007).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.