Trial reportBMC medicine2013
Mediterranean dietary pattern and depression: the PREDIMED randomized trial.
Trial report in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
144 citing papers in PubMed, 10 syntheses or guidelines pooled it, 391 citations in OpenAlex.
- Anti-inflammatory diets and mental health: a scoping review of randomized controlled trials and systematic evidence syntheses.Frontiers in nutrition · 2026Pooled it
- The Association Between Nut Consumption and Risk of Depressive Symptoms: A Meta-Analysis of Observational Studies.Nutrients · 2025Pooled it
- Intermittent Fasting as a Potential Therapeutic Instrument for Major Depression Disorder: A Systematic Review of Clinical and Preclinical Studies.International journal of molecular sciences · 2023Pooled it
- Augmenting Clinical Interventions in Psychiatric Disorders: Systematic Review and Update on Nutrition.Frontiers in psychiatry · 2021Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2018Pooled it
- Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2018Pooled it
- A Systematic Review of Behavioural Interventions Promoting Healthy Eating among Older People.Nutrients · 2018Pooled it
- Effectiveness of dietary interventions among adults of retirement age: a systematic review and meta-analysis of randomized controlled trials.BMC medicine · 2014Pooled it
- Omega-3 fatty acids reduce depressive symptoms only among the socially stressed: A corollary of the social signal transduction theory of depression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Trial
- Effects of a Mediterranean Diet Intervention on Maternal Stress, Well-Being, and Sleep Quality throughout Gestation-The IMPACT-BCN Trial.Nutrients · 2023Trial
- Trial
- Effectiveness of a Two-Year Multicomponent Intervention for the Treatment of Overweight and Obesity in Older People.Nutrients · 2022Trial
- Trial
- Economic evaluation of a dietary intervention for adults with major depression (the "SMILES" trial).BMC public health · 2018Trial
- A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial).BMC medicine · 2017Trial
- Effects of Walnut Consumption on Mood in Young Adults-A Randomized Controlled Trial.Nutrients · 2016Trial
- Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial.BMC psychiatry · 2016Trial
- Trial
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention.
methodsThis was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression.
resultsWe identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98).
conclusionsThe result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2.
trial registrationThis trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.