Evidence map›Paper›PMID 24229057›Full record

ArticleThe World Allergy Organization journal2009

Pathogenic mechanisms of idiopathic nonallergic rhinitis.

James N Baraniuk

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05984004 nacompletednot on this mapstarted 2022, after this paper: background citation

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety of Postbiotic Nasal Spray Using Killed Spores of Bacillus Subtilis DSM32444 in Healthy Volunteers

TypeinterventionalSponsorHuro Biotech Joint Stock CompanyRan2022 to 2023Enrolled60ConditionsRhino SinusitisArms0.9% NaCl isotonic saline solution, Bacillus subtilis DSM32444, inactivated
NCT05999955 nacompletednot on this mapstarted 2022, after this paper: background citation

An Open-label, Randomized, Active-controlled Study to Evaluate the Safety of Postbiotic Nasal Spray Using Inactivated DSM32444 Spores in the Treatment of Acute Rhinosinusitis, as Compared With Neomycin/ Dexamethasone/Xylometazoline Spray

TypeinterventionalSponsorHuro Biotech Joint Stock CompanyRan2022 to 2023Enrolled60ConditionsRhinosinusitis, RhinitisArmsNeomycin/ Dexameythasone/Xylometazoline, Bacillus subtilis DSM32444
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Non-atopic rhinitis at age 6 is associated with subsequent development of asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
  2. Article
  3. [Correlation between nasal mucosal temperature change and nasal airflow perception].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Association between vasomotor rhinitis and irritable bowel syndrome.Allergy & rhinology (Providence, R.I.) · 2016
    Article
  8. Article
  9. Nonallergic rhinitis.Current allergy and asthma reports · 2014
    Review
  10. Subjective nasal fullness and objective congestion.Proceedings of the American Thoracic Society · 2011
    Review
  11. Vasomotor rhinitis.Current allergy and asthma reports · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James N BaraniukDivision of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC. baraniuj@georgetown.edu.
Georgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

: Idiopathic nonallergic rhinitis (iNAR) has been difficult to define because of the long differential diagnosis of rhinopathy in the absence of allergic rhinitis. iNAR has traditionally been a diagnosis of exclusion with no clear unifying pathophysiology. Increased sensitivity to triggers such has climate changes, cold air, tobacco smoke, strong odors, and perfumes have been thought to be characteristic, but recent studies do not support this hypersensitivity hypothesis. New investigations of the local nasal environment and systemic "functional" syndromes have offered new insights into this condition. iNAR may be a heterogenous disorder that includes (1) anatomic abnormalities requiring nasal endoscopy for diagnosis, (2) incipient, local atopy (entopy), (3) dysfunction of nociceptive nerve sensor and ion channel proteins, and (4) autonomic dysfunction as found in chronic fatigue syndrome and other functional disorders.

Identifiers

PMID24229057
PMCPMC3650978
OpenAlexW2010967441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.