ArticleInternational surgery
Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients.
Article in International surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Varying negative appendectomy rates after laparoscopic appendectomy: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis.Pathogens and global health · 2022Pooled it
- Diagnostic accuracy of ultrasound in diagnosing acute appendicitis in pregnancy: a systematic review and meta-analysis.Emergency radiology · 2022Pooled it
- Neurogenic appendicopathy: an underestimated disease-systematic review of the literature.International journal of colorectal disease · 2021Pooled it
- The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review.Biochemia medica · 2016Pooled it
- Negative Appendectomy Rates and Their Correlation With the Use of Histopathology: A Clinical Audit.Cureus · 2026Article
- Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025Article
- Assessing the Efficacy of Ultrasound Imaging for Diagnosing Appendicitis in Male Patients: A Retrospective Study.Cureus · 2025Article
- Incidental Neoplasm and Histopathological Spectrum of Suspected Acute Appendicitis in Appendectomy Specimen: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Computed tomography and clinical outcomes in the diagnosis of acute appendicitis: Significance of periappendiceal fat tissue.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Significance of Histopathology of Appendectomy Specimens: Analysis From a Teaching Hospital of Pakistan.Cureus · 2023Article
- Healing Factors in Perforated and Unperforated Pediatric Appendectomies: A Descriptive Study.Journal of clinical practice and research · 2023Article
- Appendiceal Endometriosis: A Comprehensive Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Management of acute appendicitis during the COVID-19 pandemic: a retrospective cohort study.BMC surgery · 2022Article
- Accessory spleen presenting with an episode of acute appendicitis; a case report of a very rare case.International journal of surgery case reports · 2022Article
- Histopathological examination of cases with acute appendicitis, A retrospective study at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.Annals of medicine and surgery (2012) · 2022Article
- Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis.Diagnostics (Basel, Switzerland) · 2022Review
- Management of appendiceal neuroendocrine tumors in the light of new guidelines.Irish journal of medical science · 2022Article
- Incidental neuroendocrine tumor of a complete subserosal appendix: an unusual presentation of a rare anatomical variation. A case report and review of literature.BMC surgery · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to analyze the clinical benefit of histopathologic analysis of appendectomy specimens from patients with an initial diagnosis of acute appendicitis. We retrospectively analyzed the demographic and histopathologic data of 1255 patients (712 males, 543 females; age range, 17-85 years) who underwent appendectomy to treat an initial diagnosis of acute appendicitis. Patients who underwent incidental appendectomy during other surgeries were excluded from the study. Histopathologic findings of the appendectomy specimens were used to confirm the initial diagnosis. Ninety-four percent of the appendectomy specimens were positive for appendicitis. Of those, 880 were phlegmonous appendicitis, 148 were gangrenous appendicitis with perforation, and the remaining 88 showed unusual histopathologic findings. In the 88 specimens with unusual pathology, fibrous obliteration was observed in 57 specimens, carcinoid tumor in 11, Encheliophis vermicularis parasite infection in 8, granulatomous inflammation in 6, appendiceal endometriosis in 2, and 1 specimen each showed mucocele, eosinophilic infiltration, Taenia saginata parasite infection, and appendicular diverticulitis. All carcinoid tumors were located in the distal appendix. Six of the 11 carcinoid tumors were defined by histopathology as involving tubular cells, and the other 5 as involving enterochromaffin cells. Six patients had muscularis propria invasion, 2 patients had submucosa invasion, 2 patients had mesoappendix invasion, and 1 patient had serosal invasion. All patients with tumors remained disease free during the follow-up (range, 1-27 months). We conclude that when the ratio of unusual pathologic findings for appendectomy specimens is considered, it is evident that all surgical specimens should be subjected to careful histologic examination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.