ArticleMolecular pain2013
N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice.
Article in Molecular pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex.PLoS biology · 2025Article
- Activation of the glutamatergic cingulate cortical-cortical connection facilitates pain in adult mice.Communications biology · 2023Article
- Synaptic alterations and immune response are sexually dimorphic in a non-pertussis toxin model of experimental autoimmune encephalomyelitis.Experimental neurology · 2020Article
- Characterization of excitatory synaptic transmission in the anterior cingulate cortex of adult tree shrew.Molecular brain · 2017Article
- Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.Scientific reports · 2016Article
- Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.Nature reviews. Neuroscience · 2016Review
- Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex.Molecular pain · 2015Article
- Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice.Molecular pain · 2014Article
- No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex.Molecular brain · 2014Article
- Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice.Molecular painArticle
- Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex.Molecular painArticle
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Voltage gated calcium channels (VGCCs) are well known for its importance in synaptic transmission in the peripheral and central nervous system. However, the role of different VGCCs in the anterior cingulate cortex (ACC) has not been studied. Here, we use a multi-electrode array recording system (MED64) to study the contribution of different types of calcium channels in glutamatergic excitatory synaptic transmission in the ACC. We found that only the N-type calcium channel blocker ω-conotoxin-GVIA (ω-Ctx-GVIA) produced a great inhibition of basal synaptic transmission, especially in the superficial layer. Other calcium channel blockers that act on L-, P/Q-, R-, and T-type had no effect. We also tested the effects of several neuromodulators with or without ω-Ctx-GVIA. We found that N-type VGCC contributed partially to (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid- and (R)-Baclofen-induced synaptic inhibition. By contrast, the inhibitory effects of 2-Chloroadenosine and carbamoylcholine chloride did not differ with or without ω-Ctx-GVIA, indicating that they may act through other mechanisms. Our results provide strong evidence that N-type VGCCs mediate fast synaptic transmission in the ACC.
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