Evidence map›Paper›PMID 24228595›Full record

ArticleBMC biology2013

Deciphering the role of natural variation in age-related protein homeostasis.

Matt Kaeberlein

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Immune and myodegenerative pathomechanisms in inclusion body myositis.Annals of clinical and translational neurology · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Matt KaeberleinDepartment of Pathology, University of Washington, 1959 NE Pacific Street, D-514, Seattle, WA 98195-7470, USA. kaeber@uw.edu.

Funding

Mechanisms of Life Span Extension By Dietary DeprivationR01AG031108 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VAN GILST, MARC R · 2008 to 2019
$3.2M
Mechanism of lifespan and healthspan regulation by the hypoxic response transcripR01AG038518 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT · 2011 to 2015
$1.5M
Endocrine Regulation of Survival Responses in C. elegansR01AG033598 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT · 2010 to 2014
$1.5M
NIA NIH HHS R01 AG031108NIA NIH HHS R01 AG033598NIA NIH HHS R01 AG038518
6 · The paper itself

Abstract

Understanding the genetic basis of age-related diseases is a critical step toward developing therapies that promote healthy aging. Numerous genes have been identified that modulate lifespan, but the influence of natural variation in aging has not been well studied. A new report utilizing a transgenic protein aggregation model in Caenorhabditis elegans has provided important tools and insights into the relationship between natural genetic variation, protein aggregation, and age-related pathology.See research article: http://www.biomedcentral.com/1741-7007/11/100.

Indexed as

Disease Models, AnimalGenetic VariationAnimalsCaenorhabditis elegansNeurodegenerative DiseasesPeptidesPeptidespolyglutamine

Identifiers

PMID24228595
PMCPMC3849513

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.