Evidence map›Paper›PMID 24228233›Full record

ArticleOncoimmunology2013

IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients.

Jeffrey L Wong, Ravikumar Muthuswamy, David L Bartlett, Pawel Kalinski

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Regulation of the Migration of Distinct Dendritic Cell Subsets.Frontiers in cell and developmental biology · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Tumor immunotherapy: New aspects of natural killer cells.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018
    Article
  11. Article
  12. Review
  13. The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis.International journal of molecular sciences · 2016
    Review
  14. Article
  15. Review
  16. The effect of CCL19/CCR7 on the proliferation and migration of cell in prostate cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jeffrey L WongDepartment of Surgery; University of Pittsburgh; Pittsburgh, PA USA.
Ravikumar Muthuswamy
David L Bartlett
Pawel Kalinski
University of Pittsburgh · USUPMC Hillman Cancer Center · US

Funding

Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
PROTEOMICS COREP01CA101944 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2005 to 2009
$8.5M
Type-1 Antigen Presenting Cells in CNS Tumors - Key to Efficient Anti-Tumor T-CelP01CA132714 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KALINSKI, PAWEL · 2009 to 2013
$6.8M
CLINICAL TRANSLATION OF 19F MRI TO VISUALIZE CANCER IMMUNOTHERAPEUTIC CELLSR01CA134633 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T., COHEN, EZRA · 2009 to 2021
$4.4M
University of Pittsburgh Clinical and Translational Science InstituteTL1RR024155 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$1.8M
Stimulatory and Suppressive NK Cell, DC, and MDSC Interactions in Human CancerF30CA165410 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WONG, JEFFREY LING-YI · 2012 to 2014
$137k
NCI NIH HHS F30 CA165410NCI NIH HHS P01 CA101944NCI NIH HHS P01 CA132714NCI NIH HHS R01 CA134633NCI NIH HHS T32 CA082084NCRR NIH HHS TL1 RR024155
6 · The paper itself

Abstract

The effective accumulation and interaction of mature dendritic cells (DCs) and naïve T cells within lymph nodes (LNs), which are driven by the CCR7-CCL19/CCL21 chemokine axis, are critical for the induction of adaptive T-cell immunity. Human natural killer (NK) cells activated by interleukin (IL)-18 exhibit a unique 'helper' activity in promoting productive DC-T cell interactions, inducing DC maturation and shifting DC-primed T-cell responses toward a T

Indexed as

adjuvantCCL19colorectal cancerdendritic cellIL-18lymph nodenatural killer cell

Identifiers

PMID24228233
PMCPMC3820810
OpenAlexW1984969049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.