ReviewAdvances in nutrition (Bethesda, Md.)2013
The connection between dietary phosphorus, cardiovascular disease, and mortality: where we stand and what we need to know.
Review in Advances in nutrition (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- The dietary burden of phosphorus and aluminum in ready-to-eat wheat flour tortillas exceeds that of corn tortillas: Implications for patients with chronic kidney disease.Food and humanity · 2026Article
- Dietary phosphorus intake and its association with metabolic syndrome and its components: a cross-sectional analysis of the UK national diet and nutrition survey (NDNS).European journal of nutrition · 2026Article
- Effects of Lowering Dietary Phosphorus Additive Intake on Mineral Metabolism in Adults with and without CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Protective effect of dietary phosphorus intake on cardiovascular mortality in asthma: evidence from NHANES 1999-2018.Frontiers in nutrition · 2025Article
- Article
- Associations of Dietary Calcium and Phosphorus With Vascular and Valvular Calcification: The ARIC Study.JACC. Advances · 2024Article
- Article
- Phosphorus - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits.Frontiers in nutrition · 2023Review
- Association between Dietary Calcium and Potassium and Diabetic Retinopathy: A Cross-Sectional Retrospective Study.Nutrients · 2022Article
- Association between serum phosphorus and mortality in NHANES 2003-2006: the effect of gender and renal function.Journal of nephrology · 2022Article
- Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation-Induced Cardiovascular Consequences in Early Metabolic Impairment.Journal of the American Heart Association · 2021Article
- Recent Advances in the Role of Diet in Bone and Mineral Disorders in Chronic Kidney Disease.Current osteoporosis reports · 2021Review
- Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke.BMC neurology · 2020Article
- Article
- Serum phosphorus levels and risk of incident dementia.PloS one · 2017Article
- Lanthanum carbonate oral powder: satisfaction, preference and adherence in French and Spanish patients with end-stage renal disease.Drugs in context · 2016Article
- Effect of phosphorus supplementation on weight gain and waist circumference of overweight/obese adults: a randomized clinical trial.Nutrition & diabetes · 2015Article
- Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment.Nutrition journal · 2015Article
- Scientific Opinion on Dietary Reference Values for phosphorus.EFSA journal. European Food Safety Authority · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Disorders of phosphorus metabolism are independent risk factors for cardiovascular disease. Because excess dietary phosphorus intake is common in the general population and plays a central role in disturbances in phosphorus homeostasis, these findings have fueled interest in restricting phosphorus intake as a potential therapy for improving cardiovascular outcomes. Although experimental and observational data support this possibility, current limitations in the assessment of dietary phosphorus consumption in free-living populations and the lack of reliable biomarkers of the effects of dietary phosphorus on cardiovascular health pose major barriers to the design and conduct of trials assessing the efficacy of phosphorus restriction in improving cardiovascular health. Fibroblast growth factor 23 and Klotho are novel mediators of phosphorus metabolism that are tightly linked to dietary phosphorus intake and show promise as integrated biomarkers of phosphorus excess and its long-term health consequences. Advances in the understanding of how these hormones are associated with diet and phosphorus metabolism will likely bolster future efforts to assess the true health consequences of excess phosphorus intake and whether restricting phosphorus intake has salutary effects on cardiovascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.