ReviewAdvances in nutrition (Bethesda, Md.)2013
Treatment of parenteral nutrition-associated liver disease: the role of lipid emulsions.
Review in Advances in nutrition (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Enteral lipid supplements for the prevention and treatment of parenteral nutrition-associated liver disease in infants.The Cochrane database of systematic reviews · 2026Pooled it
- Single-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.Annals of surgical treatment and research · 2026Article
- Effects of intravenous lipid emulsions on Jurkat cells assessed using label-free deformability cytometry.Scientific reports · 2025Article
- Regression of intestinal failure-associated liver disease by alteration of lipid emulsion regime in home parenteral nutrition: A case report.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Article
- Intestinal failure-associated liver disease model: a reduced phytosterol intravenous lipid emulsion prevents liver injury.Pediatric research · 2025Article
- Inflammatory processes involved in the alteration of liver function biomarkers in adult hospitalized patients treated with parenteral nutrition.Frontiers in nutrition · 2023Article
- Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.Nutrients · 2022Review
- NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.Hepatology (Baltimore, Md.) · 2021Article
- Lipid-Free Parenteral Nutrition Is Associated with an Increased Risk of Hepatic Dysfunction in Surgical Critically Ill Patients: A Retrospective Observational Study.Healthcare (Basel, Switzerland) · 2021Article
- Parenteral Nutrition and Oxidant Load in Neonates.Nutrients · 2021Review
- Risk Scoring System of Mortality and Prediction Model of Hospital Stay for Critically Ill Patients Receiving Parenteral Nutrition.Healthcare (Basel, Switzerland) · 2021Article
- Lipid-Free PN is Associated with an Increased Risk of Hyperbilirubinemia in Surgical Critically Ill Patients with Admission Hepatic Disorder: A Retrospective Observational Study.Therapeutics and clinical risk management · 2021Article
- Monitoring chronological change by liver-to-spleen attenuation ratio for secondary hepatic steatosis for a short term.Clinical journal of gastroenterology · 2020Article
- Impaired Gut-Systemic Signaling Drives Total Parenteral Nutrition-Associated Injury.Nutrients · 2020Article
- Mechanisms of Parenteral Nutrition-Associated Liver and Gut Injury.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020Review
- Effects of total parenteral nutrition on drug metabolism gene expression in mice.Acta pharmaceutica Sinica. B · 2020Article
- No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition-Associated Liver Injury in a Novel Extensive Short Bowel Animal Model.JPEN. Journal of parenteral and enteral nutrition · 2018Article
- Inpatient outcomes of preterm infants receiving ω-3 enriched lipid emulsion (SMOFlipid): an observational study.European journal of pediatrics · 2018Observational
- Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.Nature communications · 2018Article
- Current treatment paradigms in pediatric short bowel syndrome.Clinical journal of gastroenterology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Parenteral nutrition is a life-saving therapy for infants with intestinal failure. However, long-term parenteral nutrition carries the risk of progressive liver disease. Substantial data has implicated components of parenteral soybean oil in the pathogenesis of parenteral nutrition-associated liver disease (PNALD). Elevated serum concentrations of phytosterols, an abundance of omega-6 polyunsaturated fatty acids, and a relative paucity of α-tocopherol have been associated with the risk of cholestasis and hepatic injury observed in PNALD. Currently available treatment strategies include the reduction of the dose of administered parenteral soybean oil and/or the replacement of parenteral soybean oil with alternative parenteral lipid emulsions. The purpose of this review is to provide an overview of the pathogenetic mechanisms associated with the development of PNALD and the data evaluating currently available treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.