ArticleRambam Maimonides medical journal2013
Non-invasive Transcranial Magnetic Stimulation (TMS) of the Motor Cortex for Neuropathic Pain-At the Tipping Point?
Article in Rambam Maimonides medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Comparison of intermittent theta burst stimulation and high-frequency repetitive transcranial magnetic stimulation on spinal cord injury-related neuropathic pain: A sham-controlled study.The journal of spinal cord medicine · 2025Trial
- The role of low-frequency rTMS in the superior parietal cortex during time estimation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Trial
- Review
- Repetitive transcranial magnetic stimulation in central post-stroke pain: current status and future perspective.The Korean journal of pain · 2023Review
- Control of inflammation using non-invasive neuromodulation: past, present and promise.International immunology · 2022Review
- Noninvasive Transcranial Magnetic Stimulation (TMS) in Chronic Refractory Pain: A Systematic Review.Cureus · 2019Review
- Homeostatic activity regulation as a mechanism underlying the effect of brain stimulation.Bioelectronic medicine · 2019Review
- Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity.Neural regeneration research · 2019Review
- Clinical study of repetitive transcranial magnetic stimulation of the motor cortex for thalamic pain.Medicine · 2018Observational
- Low-frequency rTMS in the superior parietal cortex affects the working memory in horizontal axis during the spatial task performance.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Reversal of phantom pain and hand-to-face remapping after brachial plexus avulsion.Annals of clinical and translational neurology · 2016Article
- Short-term effects of repetitive transcranial magnetic stimulation on sleep bruxism - a pilot study.International journal of oral science · 2016Article
- Non-invasive Brain Stimulation, a Tool to Revert Maladaptive Plasticity in Neuropathic Pain.Frontiers in human neuroscience · 2016Review
- Neuroimaging chronic pain: what have we learned and where are we going?Future neurology · 2014Article
- Use of cortical stimulation in neuropathic pain, tinnitus, depression, and movement disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Article
- Pathogenesis of painful diabetic neuropathy.Pain research and treatment · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The term "neuropathic pain" (NP) refers to chronic pain caused by illnesses or injuries that damage peripheral or central pain-sensing neural pathways to cause them to fire inappropriately and signal pain without cause. Neuropathic pain is common, complicating diabetes, shingles, HIV, and cancer. Medications are often ineffective or cause various adverse effects, so better approaches are needed. Half a century ago, electrical stimulation of specific brain regions (neuromodulation) was demonstrated to relieve refractory NP without distant effects, but the need for surgical electrode implantation limited use of deep brain stimulation. Next, electrodes applied to the dura outside the brain's surface to stimulate the motor cortex were shown to relieve NP less invasively. Now, electromagnetic induction permits cortical neurons to be stimulated entirely non-invasively using transcranial magnetic stimulation (TMS). Repeated sessions of many TMS pulses (rTMS) can trigger neuronal plasticity to produce long-lasting therapeutic benefit. Repeated TMS already has US and European regulatory approval for treating refractory depression, and multiple small studies report efficacy for neuropathic pain. Recent improvements include "frameless stereotactic" neuronavigation systems, in which patients' head MRIs allow TMS to be applied to precise underlying cortical targets, minimizing variability between sessions and patients, which may enhance efficacy. Transcranial magnetic stimulation appears poised for the larger trials necessary for regulatory approval of a NP indication. Since few clinicians are familiar with TMS, we review its theoretical basis and historical development, summarize the neuropathic pain trial results, and identify issues to resolve before large-scale clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.