ArticleTherapeutic advances in neurological disorders2013
Notch signalling in adult neurons: a potential target for microtubule stabilization.
Article in Therapeutic advances in neurological disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Cytoskeleton dysfunction of motor neuron in spinal muscular atrophy.Journal of neurology · 2024Review
- Neuronal Senescence in the Aged Brain.Aging and disease · 2023Review
- Conserved gene signatures shared amongFrontiers in molecular biosciences · 2023Article
- Role of Notch signaling in neurovascular aging and Alzheimer's disease.Seminars in cell & developmental biology · 2021Article
- Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action.PloS one · 2021Article
- Article
- The role of the protein-RNA recognition code in neurodegeneration.Cellular and molecular life sciences : CMLS · 2019Review
- The expression of the nicotinic acetylcholine receptor α3 subunit in the brains of patients with Alzheimer's disease and its effects on α- and γ-secretases and Notch signal transduction in SH-SY5Y cells.International journal of clinical and experimental pathology · 2019Article
- Role of Microtubule-Associated Protein in Autism Spectrum Disorder.Neuroscience bulletin · 2018Review
- Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.Nature communications · 2017Article
- Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.International journal of molecular sciences · 2017Review
- Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia.Molecular neurodegeneration · 2015Review
- Femoral nerve regeneration and its accuracy under different injury mechanisms.Neural regeneration research · 2015Article
- Axonal transport defects in Alzheimer's disease.Molecular neurobiology · 2015Review
- Neurodegeneration and microtubule dynamics: death by a thousand cuts.Frontiers in cellular neuroscience · 2015Review
- VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Role of Notch-1 signaling pathway in PC12 cell apoptosis induced by amyloid beta-peptide (25-35).Neural regeneration research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoskeletal dysfunction has been proposed during the last decade as one of the main mechanisms involved in the aetiology of several neurodegenerative diseases. Microtubules are basic elements of the cytoskeleton and the dysregulation of microtubule stability has been demonstrated to be causative for axonal transport impairment, synaptic contact degeneration, impaired neuronal function leading finally to neuronal loss. Several pathways are implicated in the microtubule assembly/disassembly process. Emerging evidence is focusing on Notch as a microtubule dynamics regulator. We demonstrated that activation of Notch signalling results in increased microtubule stability and changes in axonal morphology and branching. By contrast, Notch inhibition leads to an increase in cytoskeleton plasticity with intense neurite remodelling. Until now, several microtubule-binding compounds have been tested and the results have provided proof of concept that microtubule-binding agents or compounds with the ability to stabilize microtubules may have therapeutic potential for the treatment of Alzheimer's disease and other neurodegenerative diseases. In this review, based on its key role in cytoskeletal dynamics modulation, we propose Notch as a new potential target for microtubule stabilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.