ArticleInternational journal of biomedical nanoscience and nanotechnology2013
Protein expression profiles of intestinal epithelial co-cultures: effect of functionalised carbon nanotube exposure.
Article in International journal of biomedical nanoscience and nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro.Antioxidants (Basel, Switzerland) · 2020Article
- Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials.Journal of nanobiotechnology · 2019Article
- Electronic platform for real-time multi-parametric analysis of cellular behavior post-exposure to single-walled carbon nanotubes.Biosensors & bioelectronics · 2015Article
- Adsorption of bisphenol A to a carbon nanotube reduced its endocrine disrupting effect in mice male offspring.International journal of molecular sciences · 2014Article
- Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture.Journal of applied toxicology : JAT · 2013Article
- Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes.Proteomes · 2013Article
- Comparison of nanotube-protein corona composition in cell culture media.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps.International journal of biomedical nanoscience and nanotechnology · 2013Article
- Issues and applications in label-free quantitative mass spectrometry.International journal of proteomics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
To assess the biological effects of low level, water dispersible, functionalised carbon nanotube (f-CNT) exposure in an in vitro model simulating the digestive tract, cellular protein expression was quantified and compared using label-free quantitative mass spectrometry (LFQMS). Co-cultured cells were exposed to well-characterised SWCNT-COOH, MWCNT-COOH, and MWCNT-PVP. The relative expression of 2,282 unique proteins was compared across the dose groups. 428 proteins were found to be differentially expressed. At the high dose, the extent of differential protein expression was CNT-specific and directly related to CNT colloidal stability. Cells responded to low level MWCNT-PVP exposure with three-fold greater differential expression. Bioinformatic analysis indicated significant and f-CNT-specific effects on relevant molecular and cellular functions and canonical pathways, with little overlap across f-CNT type and in the absence of overt toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.