Evidence map›Paper›PMID 24227924›Full record

ArticleClinical epidemiology2013

Comorbidity and survival of Danish patients with colon and rectal cancer from 2000-2011: a population-based cohort study.

Eva Bjerre Ostenfeld, Mette Nørgaard, Reimar Wernich Thomsen, Lene Hjerrild Iversen, Jacob Bonde Jacobsen, Mette Søgaard

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Article in Clinical epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
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27citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Eva Bjerre OstenfeldDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark ; Department of Surgery A, Aalborg University Hospital, Aalborg, Denmark.
Mette Nørgaard
Reimar Wernich Thomsen
Lene Hjerrild Iversen
Jacob Bonde Jacobsen
Mette Søgaard

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate recent trends in the prevalence and impact of comorbidity on colorectal cancer (CRC) survival in the Central Region of Denmark. MATERIAL AND

methodsUsing the Danish National Registry of Patients, we identified 5,777 and 2,964 patients with a primary colon or rectal cancer, respectively, from 2000 through 2011. We estimated survival according to Charlson Comorbidity Index scores and computed mortality rate ratios (MRRs) using Cox proportional hazard regression analysis, adjusting for age and sex.

resultsMore than one-third of CRC patients had comorbidity at diagnosis. During the study period, 1-year survival increased substantially in colon cancer patients with Charlson score 0 (72% to 80%) and modestly for Charlson score 3+ patients (43% to 46%). Using colon cancer patients with Charlson score 0 as reference, adjusted 1-year MRRs in patients with Charlson score 3+ were 2.19 (95% confidence interval [CI]: 1.57-3.05) in 2000-2002 and 2.56 (95% CI: 1.96-3.35) in 2009-2011. One-year survival after rectal cancer improved from 81% to 87% in patients with Charlson score 0 and from 56% to 60% in Charlson score 3+. Corresponding MRRs in patients with Charlson 3+ were 2.21 (95% CI: 1.33-3.68) in 2000-2002 and 3.09 (95% CI: 1.91-5.00) in 2009-2011 using Charlson score 0 as reference. Five-year MRRs did not differ substantially from 1-year MRRs.

conclusionComorbidity was common among CRC patients and was associated with poorer prognosis. We observed improved survival from 2000 to 2011 for all comorbidity levels, with least improvement for colon cancer patients with comorbid conditions.

Indexed as

coloncomorbidityDenmarkepidemiologyneoplasmsrectalsurvival

Identifiers

PMID24227924
PMCPMC3820479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.