ArticleMolecular biology of the cell2014
Centrosome-dependent asymmetric inheritance of the midbody ring in Drosophila germline stem cell division.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Pooled it
- Mitotic and meiotic midbody remnants: Divergent architectures with distinct clinical applications.Cell genomics · 2026Review
- Article
- Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling.bioRxiv : the preprint server for biology · 2026Article
- Bridges under construction: the dynamics of ring canal expansion during Drosophila oogenesis.Developmental biology · 2026Review
- Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche.Communications biology · 2026Article
- Asymmetric division of stem cells and its cancer relevance.Cell regeneration (London, England) · 2024Review
- Towards understanding centriole elimination.Open biology · 2023Review
- Asymmetric Histone Inheritance: Establishment, Recognition, and Execution.Annual review of genetics · 2022Review
- Functional midbody assembly in the absence of a central spindle.The Journal of cell biology · 2022Article
- New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation.Molecular biology of the cell · 2022Review
- Cytokinetic Abscission Regulation in Neural Stem Cells and Tissue Development.Current stem cell reports · 2021Article
- Centromere function in asymmetric cell division inOpen biology · 2021Review
- Stem cells' centrosomes: How can organelles identified 130 years ago contribute to the future of regenerative medicine?World journal of stem cells · 2021Review
- Live imaging of the Drosophila ovarian niche shows spectrosome and centrosome dynamics during asymmetric germline stem cell division.Development (Cambridge, England) · 2021Article
- Article
- Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.The Journal of cell biology · 2021Article
- Centrosome-centric view of asymmetric stem cell division.Open biology · 2021Review
- Asymmetric inheritance of epigenetic states in asymmetrically dividing stem cells.Current opinion in cell biology · 2020Review
- Asymmetric cell division and replicative aging: a new perspective from the spindle poles.Current genetics · 2020Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Many stem cells, including Drosophila germline stem cells (GSCs), divide asymmetrically, producing one stem cell and one differentiating daughter. Cytokinesis is often asymmetric, in that only one daughter cell inherits the midbody ring (MR) upon completion of abscission even in apparently symmetrically dividing cells. However, whether the asymmetry in cytokinesis correlates with cell fate or has functional relevance has been poorly explored. Here we show that the MR is asymmetrically segregated during GSC divisions in a centrosome age-dependent manner: male GSCs, which inherit the mother centrosome, exclude the MR, whereas female GSCs, which we here show inherit the daughter centrosome, inherit the MR. We further show that stem cell identity correlates with the mode of MR inheritance. Together our data suggest that the MR does not inherently dictate stem cell identity, although its stereotypical inheritance is under the control of stemness and potentially provides a platform for asymmetric segregation of certain factors.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.