Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Early auditory processing in area V5/MT+ of the congenitally blind brain.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Stimulus-responsive and task-dependent activations in occipital regions during pitch perception by early blind listeners.Human brain mapping · 2024Article
- Differential Auditory and Visual Phase-Locking Are Observed during Audio-Visual Benefit and Silent Lip-Reading for Speech Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Investigating the neurochemistry of the human visual system using magnetic resonance spectroscopy.Brain structure & function · 2022Review
- Study of extravisual resting-state networks in pituitary adenoma patients with vision restoration.BMC neuroscience · 2022Article
- Brain-Machine Interfaces to Assist the Blind.Frontiers in human neuroscience · 2021Review
- The Effect of Congenital and Acquired Bilateral Anophthalmia on Brain Structure.Neuro-ophthalmology (Aeolus Press) · 2021Article
- Article
- Altered Intrinsic and Casual Functional Connectivities of the Middle Temporal Visual Motion Area Subregions in Chess Experts.Frontiers in neuroscience · 2020Article
- Altered Temporal Dynamic Intrinsic Brain Activity in Late Blindness.BioMed research international · 2020Article
- Functional Segregation of the Middle Temporal Visual Motion Area Revealed With Coactivation-Based Parcellation.Frontiers in neuroscience · 2020Article
- Compensatory Cross-Modal Plasticity Persists After Sight Restoration.Frontiers in neuroscience · 2020Article
- Sensitive Period for Cognitive Repurposing of Human Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Early Blindness Shapes Cortical Representations of Auditory Frequency within Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Responses in area hMT+ reflect tuning for both auditory frequency and motion after blindness early in life.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Development of visual category selectivity in ventral visual cortex does not require visual experience.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Task-specific reorganization of the auditory cortex in deaf humans.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Absence of visual experience modifies the neural basis of numerical thinking.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Using magnetic resonance imaging to assess visual deficits: a review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2016Review
- The Effect of Early Visual Deprivation on the Neural Bases of Auditory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Adaptive Pulvinar Circuitry Supports Visual Cognition.Trends in cognitive sciences · 2016Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Previous imaging studies of congenital blindness have studied individuals with heterogeneous causes of blindness, which may influence the nature and extent of cross-modal plasticity. Here, we scanned a homogeneous group of blind people with bilateral congenital anophthalmia, a condition in which both eyes fail to develop, and, as a result, the visual pathway is not stimulated by either light or retinal waves. This model of congenital blindness presents an opportunity to investigate the effects of very early visual deafferentation on the functional organization of the brain. In anophthalmic animals, the occipital cortex receives direct subcortical auditory input. We hypothesized that this pattern of subcortical reorganization ought to result in a topographic mapping of auditory frequency information in the occipital cortex of anophthalmic people. Using functional MRI, we examined auditory-evoked activity to pure tones of high, medium, and low frequencies. Activity in the superior temporal cortex was significantly reduced in anophthalmic compared with sighted participants. In the occipital cortex, a region corresponding to the cytoarchitectural area V5/MT+ was activated in the anophthalmic participants but not in sighted controls. Whereas previous studies in the blind indicate that this cortical area is activated to auditory motion, our data show it is also active for trains of pure tone stimuli and in some anophthalmic participants shows a topographic mapping (tonotopy). Therefore, this region appears to be performing early sensory processing, possibly served by direct subcortical input from the pulvinar to V5/MT+.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.