ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- EphA4 Mediates EphrinB1-Dependent Adhesion in Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Live imaging of retinotectal mapping reveals topographic map dynamics and a previously undescribed role for Contactin 2 in map sharpening.Development (Cambridge, England) · 2021Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.Scientific reports · 2017Article
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The assembly of developing motor neurons depends on an interplay between spontaneous activity, type II cadherins and gap junctions.Development (Cambridge, England) · 2017Article
- Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- Retinal waves regulate afferent terminal targeting in the early visual pathway.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity.Neural development · 2014Article
- A long Stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging.Nature communications · 2014Article
- Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Emergence of motor circuit activity.PloS one · 2014Article
- Article
- The Wiring of Developing Sensory Circuits-From Patterned Spontaneous Activity to Synaptic Plasticity Mechanisms.Frontiers in neural circuitsReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Classic studies have proposed that genetically encoded programs and spontaneous activity play complementary but independent roles in the development of neural circuits. Recent evidence, however, suggests that these two mechanisms could interact extensively, with spontaneous activity affecting the expression and function of guidance molecules at early developmental stages. Here, using the developing chick spinal cord and the mouse visual system to ectopically express the inwardly rectifying potassium channel Kir2.1 in individual embryonic neurons, we demonstrate that cell-intrinsic blockade of spontaneous activity in vivo does not affect neuronal identity specification, axon pathfinding, or EphA/ephrinA signaling during the development of topographic maps. However, intrinsic spontaneous activity is critical for axon branching and pruning once axonal growth cones reach their correct topographic position in the target tissues. Our experiments argue for the dissociation of spontaneous activity from hard-wired developmental programs in early phases of neural circuit formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.