Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Cortical reorganization after long-term adaptation to retinal lesions in humans.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- Recent Developments in Research to Make the World Better for People with Low Vision.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Ischemia-Induced Neurodegeneration in Glaucoma: Mechanistic Insights and Translational Opportunities for Psychoplastogen-Based Therapies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Examining oculomotor behavior in central vision loss with a gaze-contingent display.bioRxiv : the preprint server for biology · 2025Article
- Characterization of contrast-mediated collinear interactions in the human visual system.Scientific reports · 2025Article
- Is the Normal Periphery in Young Adults a Good Model for Reading in the Presence of Central Vision Loss?Investigative ophthalmology & visual science · 2025Article
- Learning Improves Peripheral Vision Via Enhanced Cortico-Cortical Communications.Neuroscience bulletin · 2024Article
- The Bouma law accounts for crowding in 50 observers.Journal of vision · 2023Article
- Cortical Reorganization After Optical Alignment in Strabismic Patients Outside of Critical Period.Investigative ophthalmology & visual science · 2023Article
- Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia.Investigative ophthalmology & visual science · 2023Article
- Training With Simulated Scotoma Leads to Behavioral Improvements Through at Least Two Distinct Mechanisms.Investigative ophthalmology & visual science · 2023Article
- Oculomotor responses of the visual system to an artificial central scotoma may not represent genuine visuomotor adaptation.Journal of vision · 2022Article
- The generality of the critical spacing for crowded optotypes: From Bouma to the 21st century.Journal of vision · 2021Article
- Perceptual learning of a crowding task: Effects of anisotropy and optotype.Journal of vision · 2021Article
- Dissecting (un)crowding.Journal of vision · 2021Article
- How do visual skills relate to action video game performance?Journal of vision · 2021Article
- Saccadic adaptation in the presence of artificial central scotomas.Journal of vision · 2021Article
- Behavioural Adaptation to Hereditary Macular Dystrophy: A Systematic Review on the Effect of Early Onset Central Field Loss on Peripheral Visual Abilities.The British and Irish orthoptic journal · 2021Review
- Perspective on Vision Science-Informed Interventions for Central Vision Loss.Frontiers in neuroscience · 2021Article
- Reduced fixation stability induced by peripheral viewing does not contribute to crowding.Journal of vision · 2020Article
- Combining fixation and lateral masking training enhances perceptual learning effects in patients with macular degeneration.Journal of vision · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Single-unit recordings demonstrated that the adult mammalian visual cortex is capable of reorganizing after induced retinal lesions. In humans, whether the adult cortex is capable of reorganizing has only been studied using functional magnetic resonance imaging, with equivocal results. Here, we exploited the phenomenon of visual crowding, a major limitation on object recognition, to show that, in humans with long-standing retinal (macular) lesions that afflict the fovea and thus use their peripheral vision exclusively, the signature properties of crowding are distinctly different from those of the normal periphery. Crowding refers to the inability to recognize objects when the object spacing is smaller than the critical spacing. Critical spacing depends only on the retinal location of the object, scales linearly with its distance from the fovea, and is approximately two times larger in the radial than the tangential direction with respect to the fovea, thus demonstrating the signature radial-tangential anisotropy of the crowding zone. Using retinal imaging combined with behavioral measurements, we mapped out the crowding zone at the precise peripheral retinal locations adopted by individuals with macular lesions as the new visual reference loci. At these loci, the critical spacings are substantially smaller along the radial direction than expected based on the normal periphery, resulting in a lower scaling of critical spacing with the eccentricity of the peripheral locus and a loss in the signature radial-tangential anisotropy of the crowding zone. These results imply a fundamental difference in the substrate of cortical processing in object recognition following long-term adaptation to macular lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.