ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Safety signals in the primate amygdala.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Article
- Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Perigenual and Subgenual Anterior Cingulate Afferents Converge on Common Pyramidal Cells in Amygdala Subregions of the Macaque.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Stimulus-Based Extinction Generalization: Neural Correlates and Modulation by Cortisol.The international journal of neuropsychopharmacology · 2021Article
- A global framework for a systemic view of brain modeling.Brain informatics · 2021Article
- Representation of Fear of Heights by Basolateral Amygdala Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Salient safety conditioning improves novel discrimination learning.Behavioural brain research · 2021Article
- Neural correlates of safety learning.Behavioural brain research · 2021Article
- Prefrontal cortical and nucleus accumbens contributions to discriminative conditioned suppression of reward-seeking.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Multisensory Neurons in the Primate Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Long time-scales in primate amygdala neurons support aversive learning.Nature communications · 2018Article
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- Article
- A neuronal basis for fear discrimination in the lateral amygdala.Nature communications · 2018Article
- Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders.Brain sciences · 2017Article
- Differential Recruitment of Competing Valence-Related Amygdala Networks during Anxiety.Neuron · 2017Article
- Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to distinguish danger from safety is crucial for survival. On the other hand, anxiety disorders can result from failures to dissociate safe cues from those that predict dangerous outcomes. The amygdala plays a major role in learning and signaling danger, and recently, evidence accumulates that it also acquires information to signal safety. Traditionally, safety is explored by paradigms that change the value of a previously dangerous cue, such as extinction or reversal; or by paradigms showing that a safe cue can inhibit responses to another danger-predicting cue, as in conditioned-inhibition. In real-life scenarios, many cues are never paired or tested with danger and remain neutral all along. A detailed study of neural responses to unpaired conditioned-stimulus (CS-) can therefore indicate whether information on safety-by-comparison is also acquired in the amygdala. We designed a multiple-CS study, with CS- from both visual and auditory modalities. Using discriminative aversive-conditioning, we find that responses in the primate amygdala develop for CS- of the same modality and of a different modality from that of the aversive CS+. Moreover, we find that responses are comparable in proportion, sign (increase/decrease), onset, and magnitude. These results indicate that the primate amygdala actively acquires signals about safety, and strengthen the hypothesis that failure in amygdala processing can result in failure to distinguish dangerous cues from safe ones and lead to maladaptive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.