ArticleJournal of magnetic resonance imaging : JMRI2014
Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.
Article in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Improved MRI methods to quantify retinal and choroidal blood flow applied to a model of glaucoma.Frontiers in ophthalmology · 2024Article
- Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Stem Cells as Drug-like Biologics for Mitochondrial Repair in Stroke.Pharmaceutics · 2020Review
- Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy.Neural regeneration research · 2020Review
- The brain and eye: Treating cerebral and retinal ischemia through mitochondrial transfer.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance.AJNR. American journal of neuroradiology · 2019Article
- Eye Opener in Stroke.Stroke · 2019Article
- Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia.Neurobiology of disease · 2014Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo compare basal retinal and cerebral blood flow (BF) values using continuous arterial spin labeling (CASL) MRI and fluorescent microspheres. MATERIALS AND
methodsA total of 41 animals were used. BF was measured using an established microsphere technique (a mixture of 2.5 million 8 μm green and 0.5 million 10 μm blue fluorescent microspheres) and CASL MRI blood flow measurement in the rat retina and brain at 7 Tesla (T) and 11.7T, respectively.
resultsRetinal BF by MRI was 1.18 ± 0.57 mL/g/min and choroidal BF was 8.14 ± 1.8 mL/g/min (n = 6). Microsphere retinal BF was 9.12 ± 2.8 μL/min per tissue and choroidal BF was 73.38 ± 44 μL/min per tissue (n = 18), corresponding to a retinal BF value of 1.22 ± 0.36 mL/g/min by means of a wet weight conversion. The wet-weight of the choroid could not be determined. To corroborate our findings, cerebral BF (CBF) by MRI was also analyzed. In the cerebral cortices, CBF was 0.91 ± 0.29 mL/g/min (n = 14) by CASL MRI and 1.09 ± 0.37 mL/g/min (n = 6) by microspheres. There were no significant differences found between MRI and microsphere blood flow in the retina and brain.
conclusionBF values in the rat retina and cerebral cortex by MRI are in agreement with those obtained by the microsphere technique.
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