Evidence map›Paper›PMID 24227634›Full record

ReviewReviews in medical virology2014

Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity.

Jop Jans, Marloes Vissers, Jacco G M Heldens, Marien I de Jonge, Ofer Levy, Gerben Ferwerda

Open access · greenAbstract readReview
In one paragraph

Review in Reviews in medical virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Journal of virology · 2017
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jop JansDepartment of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands.
Marloes Vissers
Jacco G M Heldens
Marien I de Jonge
Ofer Levy
Gerben Ferwerda
Radboud University Nijmegen · NLRadboud University Medical Center · NLHarvard University · US

Funding

Modeling distinct neonatal purine metabolism to inform vaccine developmentR01AI100135 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2012 to 2016
$2.5M
NIAID NIH HHS 1R01AI100135-01NIAID NIH HHS R01 AI100135
6 · The paper itself

Abstract

RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.

Indexed as

Immunity, InnateAntibodies, ViralHumansInfantInfant, NewbornReceptors, IgGRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAntibodies, ViralReceptors, IgG

Identifiers

PMID24227634
PMCPMC3973536
OpenAlexW2133517065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.