ArticleChemical senses2014
Extensive lesions in the gustatory cortex in the rat do not disrupt the retention of a presurgically conditioned taste aversion and do not impair unconditioned concentration-dependent licking of sucrose and quinine.
Article in Chemical senses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025Article
- 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications.Physiology & behavior · 2020Review
- Chemospecific deficits in taste sensitivity following bilateral or right hemispheric gustatory cortex lesions in rats.The Journal of comparative neurology · 2020Article
- Cortical processing of chemosensory and hedonic features of taste in active licking mice.Journal of neurophysiology · 2020Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- An Insula-Central Amygdala Circuit for Guiding Tastant-Reinforced Choice Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Overlapping Representation of Primary Tastes in a Defined Region of the Gustatory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- Measurement of Behavioral Taste Responses in Mice: Two-Bottle Preference, Lickometer, and Conditioned Taste-Aversion Tests.Current protocols in mouse biology · 2016Article
- Sensory Cortical Activity Is Related to the Selection of a Rhythmic Motor Action Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Bilateral lesions in a specific subregion of posterior insular cortex impair conditioned taste aversion expression in rats.The Journal of comparative neurology · 2016Article
- Behavioral analyses of taste function and ingestion in rodent models.Physiology & behavior · 2015Article
- Cocaine decreases saccharin preference without altering sweet taste sensitivity.Pharmacology, biochemistry, and behavior · 2015Article
- Unconditioned oromotor taste reactivity elicited by sucrose and quinine is unaffected by extensive bilateral damage to the gustatory zone of the insular cortex in rats.Brain research · 2015Article
- Gustatory insular cortex, aversive taste memory and taste neophobia.Neurobiology of learning and memory · 2015Article
- Extensive Gustatory Cortex Lesions Significantly Impair Taste Sensitivity to KCl and Quinine but Not to Sucrose in Rats.PloS one · 2015Article
- Extensive lesions in rat insular cortex significantly disrupt taste sensitivity to NaCl and KCl and slow salt discrimination learning.PloS one · 2015Article
- Restoration of quinine-stimulated Fos-immunoreactive neurons in the central nucleus of the amygdala and gustatory cortex following reinnervation or cross-reinnervation of the lingual taste nerves in rats.The Journal of comparative neurology · 2014Article
- High-resolution lesion-mapping strategy links a hot spot in rat insular cortex with impaired expression of taste aversion learning.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Although damage to gustatory cortex (GC) in the rat has been reported to severely impair, if not eliminate, retention of a presurgically conditioned taste aversion (CTA), it has equivocal effects on taste preference as measured by intake tests. Because intake tests can be influenced by nongustatory (e.g., postingestive) factors, we employed the brief-access taste test to assess the effects of ibotenic acid-induced lesions targeting the GC on unconditioned licking to a sucrose and then a quinine concentration series in a specialized lickometer. As a functional lesion assessment, a presurgical CTA to 0.1M NaCl was established in thirsty rats by following 15-min intake with intraperitoneal administration of either LiCl (or NaCl for control) on 2 occasions. Both conditioned sham-operated (SHAM) rats and rats with histologically confirmed extensive damage to the GC (GCX) avoided a NaCl concentration series relative to unconditioned controls in a postsurgical brief-access CTA test, with no difference between the surgical groups in their responses to NaCl or similar concentrations of KCl. GCX rats also did not differ from SHAM rats in the EC50 of concentration-response functions for sucrose or quinine. Clearly, the critical cortical area required for the retention of a presurgical CTA falls outside of the extensive area of damage, which was well centered within the conventionally defined gustatory zone of the insular cortex. The absence of an effect on unconditioned responsiveness to sucrose and quinine suggests that the damaged region is also unnecessary for the normal expression of affective licking responses to tastants.
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