ReviewJournal of human hypertension2014
C-reactive protein and hypertension.
Review in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- The Dual Edge of zinc: linking excessive intake to obesity, diabetes, hypertension, and cardiovascular risks.Acta biochimica Polonica · 2025Pooled it
- Supplementation of Olive Oil and Flaxseed Oil on Blood Pressure and Inflammation in Healthy and At-Risk Adults: A Systematic Literature Review and Meta-Analysis.Current hypertension reviews · 2024Pooled it
- The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Association between serum level of C-reactive protein and risk of cardiovascular events based on cohort studies.Journal of human hypertension · 2021Pooled it
- The effects of a 12-week jump rope exercise program on abdominal adiposity, vasoactive substances, inflammation, and vascular function in adolescent girls with prehypertension.European journal of applied physiology · 2019Trial
- Serum albumin and hypertension: The mediating roles of BMI, C-reactive protein and extracellular fluid.Asia Pacific journal of clinical nutrition · 2026Article
- Synergistic Role of Aerobic Exercise and Vitamin C in Reducing Hypertension and Restoring Redox-Inflammatory Balance.Nutrients · 2026Article
- C-reactive protein in cardiovascular disease: clinical associations, conformation-dependent biology, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Helicobacter pylori seroprevalence and its association with prevalent and incident blood pressure and haemoglobin A1c in the US-based National Longitudinal Study of Adolescent to Adult Health.BMJ public health · 2026Article
- Analysis of inflammatory markers in patients with abnormal circadian rhythm of blood pressure.Archives of medical science : AMS · 2026Article
- Six Weeks of Boxing Training Lowers Blood Pressure and Improves Vascular Function in Young Men and Women with Elevated Blood Pressure or Stage 1 Hypertension.Sports (Basel, Switzerland) · 2026Article
- The Systemic Link Between Oral Health and Cardiovascular Disease: Contemporary Evidence, Mechanisms, and Risk Factor Implications.Diseases (Basel, Switzerland) · 2025Review
- Observational
- The acute impact of resistance exercise training on cardiovascular parameters in trained and untrained adults with high blood pressure.European journal of applied physiology · 2025Article
- Evaluating the visceral adiposity inflammatory index for enhanced stroke risk assessment.Scientific reports · 2025Article
- Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients.Future cardiology · 2025Article
- Mechanism of action of exercise regulating intestinal microflora to improve spontaneous hypertension in rats.Biomolecules & biomedicine · 2025Article
- Somatic Symptoms Are Associated With Elevated Blood Pressure and Epstein-Barr Virus Antibodies Among Shuar of the Ecuadorian Amazon.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Diagnostic Utility of Combining Homocysteine, Lipoprotein-Associated Phospholipase A2, and the C-Reactive Protein-to-Albumin Ratio for Assessing Carotid Atherosclerosis and Plaque Stability in Patients with Essential Hypertension.Cardiovascular toxicology · 2025Article
- Prospective Analysis of Central Nervous System Infection Risks in Varicella-Zoster Virus Reactivation Cases: A Single-Center Prospective Study of 1030 Cases.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in individuals who are at intermediate risk. This paper reviews the role of CRP in hypertension. In hypertensive individuals, CRP levels associate with vascular stiffness, atherosclerosis and the development of end-organ damage and cardiovascular events. Data suggest that some anti-hypertensive medications may lower CRP levels in a manner independent of their effect on blood pressure. In individuals who are normotensive at baseline, CRP levels have been shown in multiple cohorts to foretell the development of hypertension on follow-up. Whether genetic variability that influences circulating levels of CRP independent of environmental and behavioral factors can also be used in a similar manner to predict the change in blood pressure and development of hypertension is controversial. In addition to its role as a biomarker, experimental studies have unraveled an active direct participation of CRP in the development of endothelial dysfunction, vascular stiffness and elevated blood pressure. CRP has also been implicated as a mediator of vascular remodeling in response to injury and cardiac remodeling in response to pressure overload. Emerging data may reveal novel vascular inflammatory pathways and identify new targets for treatment of vascular pathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.