ArticleScientific reports2013
Single-neuron criticality optimizes analog dendritic computation.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Mapping and modeling age-related changes in intrinsic neural timescales.Communications biology · 2025Article
- Is the Papez circuit the location of the elusive episodic memory engram?IBRO neuroscience reports · 2024Article
- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Compressive sensing of functional connectivity maps from patterned optogenetic stimulation of neuronal ensembles.Patterns (New York, N.Y.) · 2023Article
- Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures.PloS one · 2022Article
- Article
- Single-neuron dynamical effects of dendritic pruning implicated in aging and neurodegeneration: towards a measure of neuronal reserve.Scientific reports · 2021Article
- Optimal Organization of Functional Connectivity Networks for Segregation and Integration With Large-Scale Critical Dynamics in Human Brains.Frontiers in computational neuroscience · 2021Article
- Spatially resolved dendritic integration: towards a functional classification of neurons.PeerJ · 2020Article
- Modelling brain-wide neuronal morphology via rooted Cayley trees.Scientific reports · 2018Article
- Coexistence of critical sensitivity and subcritical specificity can yield optimal population coding.Journal of the Royal Society, Interface · 2017Article
- Emergent stochastic oscillations and signal detection in tree networks of excitable elements.Scientific reports · 2017Article
- Relationship in Pacemaker Neurons Between the Long-Term Correlations of Membrane Voltage Fluctuations and the Corresponding Duration of the Inter-Spike Interval.The Journal of membrane biology · 2017Article
- Article
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3 authors.
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Abstract
Active dendritic branchlets enable the propagation of dendritic spikes, whose computational functions remain an open question. Here we propose a concrete function to the active channels in large dendritic trees. Modelling the input-output response of large active dendritic arbors subjected to complex spatio-temporal inputs and exhibiting non-stereotyped dendritic spikes, we find that the dendritic arbor can undergo a continuous phase transition from a quiescent to an active state, thereby exhibiting spontaneous and self-sustained localized activity as suggested by experiments. Analogously to the critical brain hypothesis, which states that neuronal networks self-organize near criticality to take advantage of its specific properties, here we propose that neurons with large dendritic arbors optimize their capacity to distinguish incoming stimuli at the critical state. We suggest that "computation at the edge of a phase transition" is more compatible with the view that dendritic arbors perform an analog rather than a digital dendritic computation.
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