ArticleThe Journal of biological chemistry2013
Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Biosynthesis ofSynthetic and systems biotechnology · 2026Article
- Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines.Nature communications · 2025Article
- Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase.Biochemistry · 2024Article
- Biocatalytic Stereoselective Oxidation of 2-Arylindoles.Journal of the American Chemical Society · 2024Article
- Secondary Metabolites Produced by the Blue-Cheese Ripening MoldJournal of fungi (Basel, Switzerland) · 2023Review
- Discovery, Antitumor Activity, and Fermentation Optimization of Roquefortines fromMolecules (Basel, Switzerland) · 2023Article
- Review
- Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi.ACS synthetic biology · 2019Article
- Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.Organic & biomolecular chemistry · 2018Article
- Engineering of the Filamentous FungusFrontiers in microbiology · 2018Review
- Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.Chemical reviews · 2017Review
- Physiological characterization of secondary metabolite producingFungal biology and biotechnology · 2017Article
- Joining Forces: Fermentation and Organic Synthesis for the Production of Complex Heterocycles.The Journal of organic chemistry · 2016Review
- OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30.Journal of the American Chemical Society · 2016Article
- Genome sequencing and secondary metabolism of the postharvest pathogen Penicillium griseofulvum.BMC genomics · 2016Article
- Triazaspirocycles: Occurrence, Synthesis, and Applications.Mini-reviews in organic chemistry · 2016Article
- Incorporating Fermentation into Undergraduate Laboratory Courses.Athens journal of sciences · 2015Article
- Genomic mutational analysis of the impact of the classical strain improvement program on β-lactam producing Penicillium chrysogenum.BMC genomics · 2015Article
- Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis.BMC microbiology · 2014Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Metabolic profiling and structural elucidation of novel secondary metabolites obtained from derived deletion strains of the filamentous fungus Penicillium chrysogenum were used to reassign various previously ascribed synthetase genes of the roquefortine/meleagrin pathway to their corresponding products. Next to the structural characterization of roquefortine F and neoxaline, which are for the first time reported for P. chrysogenum, we identified the novel metabolite roquefortine L, including its degradation products, harboring remarkable chemical structures. Their biosynthesis is discussed, questioning the exclusive role of glandicoline A as key intermediate in the pathway. The results reveal that further enzymes of this pathway are rather unspecific and catalyze more than one reaction, leading to excessive branching in the pathway with meleagrin and neoxaline as end products of two branches.
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