ArticleJournal of acquired immune deficiency syndromes (1999)2013
Heterogeneity among studies in rates of decline of antiretroviral therapy adherence over time: results from the multisite adherence collaboration on HIV 14 study.
Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis.BMC medicine · 2014Pooled it
- START (Supporting Treatment Adherence Readiness through Training) Improves Both HIV Antiretroviral Adherence and Viral Reduction, and is Cost Effective: Results of a Multi-site Randomized Controlled Trial.AIDS and behavior · 2021Trial
- Patient Self-Reported Adherence to Ritonavir-Boosted Darunavir Combined With Either Raltegravir or Tenofovir Disoproxil Fumarate/Emtricitabine in the NEAT001/ANRS143 Trial.Journal of acquired immune deficiency syndromes (1999) · 2018Trial
- Effectiveness of a Peer Navigation Intervention to Sustain Viral Suppression Among HIV-Positive Men and Transgender Women Released From Jail: The LINK LA Randomized Clinical Trial.JAMA internal medicine · 2018Trial
- A Randomized Controlled Trial of Rise, a Community-Based Culturally Congruent Adherence Intervention for Black Americans Living with HIV.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017Trial
- High Current CD4+ T Cell Count Predicts Suboptimal Adherence to Antiretroviral Therapy.PloS one · 2015Trial
- Parallel declines in antiretroviral therapy adherence by dried blood spot and electronic monitoring in Cape Town, South Africa.AIDS (London, England) · 2026Article
- Culturally Relevant Africultural Coping Moderates the Association Between Discrimination and Antiretroviral Adherence Among Sexual Minority Black Americans Living with HIV.AIDS and behavior · 2024Article
- Workforce migration and brain drain - A nationwide cross-sectional survey of early career psychiatrists in Nigeria.Global mental health (Cambridge, England) · 2024Article
- Daily Associations Between Alcohol Consumption and Antiretroviral Therapy (ART) Adherence Among HIV-Positive Men Who Have Sex With Men.AIDS and behavior · 2022Article
- Perceived HIV Treatment Norms Modify the Association Between HIV-Related Stigma and Adherence to Antiretroviral Therapy Among Persons Living with HIV in Baltimore, Maryland.AIDS and behavior · 2022Article
- Participants Switching to Second-Line Antiretroviral Therapy with Susceptible Virus Display Inferior Adherence and Worse Outcomes: An Observational Analysis.AIDS patient care and STDs · 2021Observational
- Smartphone-based incentives for promoting adherence to antiretroviral therapy: A randomized controlled trial.Preventive medicine reports · 2021Article
- Changes in ART Adherence Relate to Changes in depression as Well! Evidence for the Bi-directional Longitudinal Relationship Between Depression and ART Adherence from a Prospective Study of HIV Clients in Uganda.AIDS and behavior · 2020Article
- The association of provider and practice factors with HIV antiretroviral therapy adherence.AIDS (London, England) · 2019Article
- A Comparison of Plasma Efavirenz and Tenofovir, Dried Blood Spot Tenofovir-Diphosphate, and Self-Reported Adherence to Predict Virologic Suppression Among South African Women.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- BrainJournal of neuroinflammation · 2018Article
- Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance.AIDS and behavior · 2018Article
- Monitoring self-reported adherence to antiretroviral therapy in public HIV care facilities in Brazil: A national cross-sectional study.Medicine · 2018Article
- Advancing the Science and Practice of Medication Adherence.Journal of general internal medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveTo use electronic drug monitoring to determine if adherence to HIV antiretroviral therapy (ART) changes over time, whether changes are linear, and how the declines vary by study.
designWe conducted a longitudinal study of pooled data from 11 different studies of HIV-infected adults using ART. The main outcome was ART adherence (percent of prescribed doses taken) measured by electronic drug monitoring. We modeled and compared changes in adherence over time using repeated measures linear mixed effects models and generalized additive mixed models (GAMMs). Indicator variables were used to examine the impact of individual studies, and the variation across studies was evaluated using study-specific parameter estimates calculated by using interaction terms of study and time.
resultsThe mean age of the subjects was 41 years, 35% were female, most had high school education or less, and 46% were African American. In GAMMs, adherence declined over time. The GAMMs further suggested that the decline was nonlinear, and in both sets of models, there was considerable study-to-study variability in how adherence changed over time. LIMITATIONS: Findings may not be generalizable to non-US populations or to patients not in clinical studies.
conclusionsAlthough overall ART adherence declined with time, not all studies showed declines, and a number of patterns of change were seen. Studies that identify clinical and organizational factors associated with these different patterns are needed. Models of changes in adherence with time should take account of possible nonlinear effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.