ArticleNutrients2013
Vitamin B12 deficiency in relation to functional disabilities.
Article in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Vitamin B12 Deficiency Presenting as Anemia and Functional Decline in an Older Adult: A Case Report.Cureus · 2026Article
- Diabetes, Cognitive Function and Mortality Risk Among Older Hispanics.Brain sciences · 2025Article
- Sex-specific Association of Chronic Proton Pump Inhibitor Use With Reduced Bone Density and Quality.The Journal of clinical endocrinology and metabolism · 2025Article
- Dizziness and unstable gait in the older adults are associated with vestibular hypofunction, muscle dysfunction and sleep disturbance: impact on prevention of accidental falls.BMC geriatrics · 2024Article
- Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function.Aging medicine (Milton (N.S.W)) · 2024Article
- Impact of Vitamin B12 Insufficiency on the Incidence of Sarcopenia in Korean Community-Dwelling Older Adults: A Two-Year Longitudinal Study.Nutrients · 2023Article
- Vitamin B-12 malabsorption and renal function are critical considerations in studies of folate and vitamin B-12 interactions in cognitive performance: NHANES 2011-2014.The American journal of clinical nutrition · 2022Article
- Impact of Vitamin B12 Insufficiency on Sarcopenia in Community-Dwelling Older Korean Adults.International journal of environmental research and public health · 2021Article
- Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People.Nutrients · 2021Review
- Clinical Validation of a Multi-Biomarker Assay for the Evaluation of Chronic Pain Patients in a Cross-Sectional, Observational Study.Pain and therapy · 2020Article
- Article
- The Association Between Leukocyte Telomere Length and Cognitive Performance Among the American Elderly.Frontiers in aging neuroscience · 2020Article
- The Many Faces of Cobalamin (Vitamin BMayo Clinic proceedings. Innovations, quality & outcomes · 2019Review
- Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved.International journal of environmental research and public health · 2019Review
- Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Review
- [Clinical hematological symptoms of vitamin BZeitschrift fur Gerontologie und Geriatrie · 2018Review
- Long-term Metformin Therapy and Monitoring for Vitamin B12 Deficiency Among Older Veterans.Journal of the American Geriatrics Society · 2017Article
- Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.The journal of nutrition, health & aging · 2017Article
- [Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?].Der Internist · 2015Review
- [Vitamin B12 deficiency in the elderly].Zeitschrift fur Gerontologie und Geriatrie · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to assess whether symptoms, functional measures, and reported disabilities were associated with vitamin B12 (B12) deficiency when defined in three ways. Participants, aged 60 or more years of age, in 1999-2002 National Health and Nutrition Examination Surveys (NHANES) were categorized in relation to three previously used definitions of B12 deficiency: (1) serum B12 < 148 pmol/L; (2) serum B12 < 200 pmol/L and serum homocysteine > 20 μmol/L; and (3) serum B12 < 258 pmol/L or serum methylmalonic acid > 0.21 μmol/L. Functional measures of peripheral neuropathy, balance, cognitive function, gait speed, along with self-reported disability (including activities of daily living) were examined with standardized instruments by trained NHANES interviewers and technicians. Individuals identified as B12 deficient by definition 2 were more likely to manifest peripheral neuropathy OR (odds) (95% confidence intervals), p value: 9.70 (2.24, 42.07), 0.004 and report greater total disability, 19.61 (6.22, 61.86) 0.0001 after adjustments for age, sex, race, serum creatinine, and ferritin concentrations, smoking, diabetes, and peripheral artery disease. Smaller, but significantly increased, odds of peripheral neuropathy and total disability were also observed when definition 3 was applied. Functional measures and reported disabilities were associated with B12 deficiency definitions that include B12 biomarkers (homocysteine or methylmalonic acid). Further study of these definitions is needed to alert clinicians of possible subclinical B12 deficiency because functional decline amongst older adults may be correctable if the individual is B12 replete.
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Registered trials
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