ArticleProceedings. Biological sciences2014
Fitness benefits of low infectivity in a spatially structured population of bacteriophages.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Live and let die: Lysis time variability and resource limitation shape lytic bacteriophage fitness.PLoS computational biology · 2026Article
- Directed evolution of a staphylophage under biofilm and planktonic conditions.NPJ biofilms and microbiomes · 2025Article
- Spatial clustering of hosts can favor specialist parasites.Ecology and evolution · 2024Article
- Mini review advantages and limitations of lytic phages compared with chemical antibiotics to combat bacterial infections.Heliyon · 2024Review
- Bacteriophage Adsorption: Likelihood of Virion Encounter with Bacteria and Other Factors Affecting Rates.Antibiotics (Basel, Switzerland) · 2023Review
- Biological Features and In Planta Transcriptomic Analyses of aInternational journal of molecular sciences · 2022Article
- Individual-based model highlights the importance of trade-offs for virus-host population dynamics and long-term co-existence.PLoS computational biology · 2022Article
- Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks.PLoS computational biology · 2022Article
- Aerobic Conditions and Endogenous Reactive Oxygen Species Reduce the Production of Infectious MS2 Phage byViruses · 2021Article
- Hitchhiking, collapse, and contingency in phage infections of migrating bacterial populations.The ISME journal · 2020Article
- Tissue-resident T cell-derived cytokines eliminate herpes simplex virus-2-infected cells.The Journal of clinical investigation · 2020Article
- Social Bacteriophages.Microorganisms · 2020Review
- Article
- Phage Therapy Faces Evolutionary Challenges.Viruses · 2018Article
- Multiple mechanisms drive phage infection efficiency in nearly identical hosts.The ISME journal · 2018Article
- Bacteriophages affect evolution of bacterial communities in spatially distributed habitats: a simulation study.BMC microbiology · 2016Article
- Article
- Research highlight for issue 8: disease evolution and ecology across space.Evolutionary applications · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
For a parasite evolving in a spatially structured environment, an evolutionarily advantageous strategy may be to reduce its transmission rate or infectivity. We demonstrate this empirically using bacteriophage (phage) from an evolution experiment where spatial structure was maintained over 550 phage generations on agar plates. We found that a single substitution in the major capsid protein led to slower adsorption of phage to host cells with no change in lysis time or burst size. Plaques formed by phage isolates containing this mutation were not only larger but also contained more phage per unit area. Using a spatially explicit, individual-based model, we showed that when there is a trade-off between adsorption and diffusion (i.e. less 'sticky' phage diffuse further), slow adsorption can maximize plaque size, plaque density and overall productivity. These findings suggest that less infective pathogens may have an advantage in spatially structured populations, even when well-mixed models predict that they will not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.