Observational studyThe American journal of clinical nutrition2014
Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.
Observational study in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Dietary vitamin A, C, and E intake and subsequent fracture risk at various sites: A meta-analysis of prospective cohort studies.Medicine · 2020Pooled it
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- Trial
- Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis.Nature communications · 2025Article
- Association between vitamin levels and geriatric hip fractures: A cross-sectional study.Frontiers in nutrition · 2025Article
- Association between dietary vitamin E and osteoporosis in older adults in the United States.Frontiers in endocrinology · 2024Article
- Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024Review
- Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010.Journal of bone and mineral metabolism · 2023Article
- Association between dietary intake of α-tocopherol and cadmium related osteoporosis in population ≥ 50 years.Journal of bone and mineral metabolism · 2023Article
- Article
- Musculoskeletal Health of the Adults Over 50 Years of Age in Relation to Antioxidant Vitamin Intakes.Clinical nutrition research · 2022Article
- Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study.Nutrients · 2021Article
- Vitamin E beyond Its Antioxidant Label.Antioxidants (Basel, Switzerland) · 2021Review
- Is the effect of Mediterranean diet on hip fracture mediated through type 2 diabetes mellitus and body mass index?International journal of epidemiology · 2021Article
- Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort.Antioxidants (Basel, Switzerland) · 2021Article
- Milk Consumption for the Prevention of Fragility Fractures.Nutrients · 2020Review
- Review
- Article
- Bone Mineral Density in Premenopausal Women Is Associated with the Dietary Intake of α-Tocopherol: A Cross-Sectional Study.Nutrients · 2019Article
- Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival.Calcified tissue international · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.
objectiveThe objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.
designTwo cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.
resultsDuring 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48).
conclusionLow intakes and low serum concentrations of α-tocopherol are associated with an increased rate of fracture in elderly women and men.
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