ArticleJournal of translational medicine2013
Effects of selenoprotein S on oxidative injury in human endothelial cells.
Article in Journal of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Protective effect of soluble protein hydrolysate against HMolecular medicine reports · 2025Article
- Association between Human Blood Proteome and the Risk of Myocardial Infarction.Reviews in cardiovascular medicine · 2024Article
- Current views on selenoprotein S in the pathophysiological processes of diabetes-induced atherosclerosis: potential therapeutics and underlying biomarkers.Diabetology & metabolic syndrome · 2024Review
- Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes.Biological trace element research · 2023Article
- Selenium Deficiency during Pregnancy in Mice Impairs Exercise Performance and Metabolic Function in Adult Offspring.Nutrients · 2022Article
- Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective.Current heart failure reports · 2021Review
- Nomogram developed with selenoprotein S (SelS) genetic variation and clinical characteristics predicting risk of coronary artery disease in a Chinese population.Cardiovascular diagnosis and therapy · 2020Article
- Identification of the Selenoprotein S Positive UGA Recoding (SPUR) element and its position-dependent activity.RNA biology · 2019Article
- Correlation between SEPS1 gene polymorphism and type 2 diabetes mellitus: A preliminary study.Journal of clinical laboratory analysis · 2019Article
- Association of genetic polymorphisms of SelS with Type 2 diabetes in a Chinese population.Bioscience reports · 2018Article
- Differential regulation of cellular stress responses by the endoplasmic reticulum-resident Selenoprotein S (Seps1) in proliferating myoblasts versus myotubes.Physiological reports · 2018Article
- Selenoprotein S Attenuates Tumor Necrosis Factor-Mediators of inflammation · 2018Article
- Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?Cardiovascular diabetology · 2017Review
- Evidence supporting the conceptual framework of cancer chemoprevention in canines.Scientific reports · 2016Article
- The source of circulating selenoprotein S and its association with type 2 diabetes mellitus and atherosclerosis: a preliminary study.Cardiovascular diabetology · 2016Article
- Article
- An insight into the functional role of thioredoxin reductase, a selenoprotein, in maintaining normal native microbiota in the Gulf Coast tick (Amblyomma maculatum).Insect molecular biology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelenoprotein S (SelS) is an important endoplasmic reticulum and plasma membrane-located selenoprotein implicated in inflammatory responses and insulin resistance. However, the effects of SelS on endothelial cells (ECs) have not been reported. In the present study, the role of SelS in oxidative stress and the underlying mechanism were investigated in human ECs.
methodsA SelS over-expression plasmid (pc-SelS) and a SelS-siRNA plasmid were transfected into human umbilical vein endothelial cells (American Type Culture Collection, USA). The cells were divided into four groups: control, SelS over-expression (transfected with pc-SelS), vector control, and SelS knockdown (transfected with siRNA-SelS). After treating the cells with H2O2, the effects of oxidative stress and the expression of caveolin-1 (Cav-1) and protein kinase Cα (PKCα) were investigated.
resultsFollowing treatment with H2O2, over-expression of SelS significantly increased cell viability and superoxide dismutase (SOD) activity, and decreased malondialdehyde (MDA) production and Cav-1 gene and protein expression. However, no effects on PKCα were observed. In contrast, knockdown of SelS significantly decreased cell viability, SOD activity, and PKCα gene and protein expression, and increased MDA production and Cav-1 gene and protein expression.
conclusionsSelS protects ECs from oxidative stress by inhibiting the expression of Cav-1 and PKCα.
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